Early childhood HPV infection outcomes and epigenetic tests in cervical cancer screening

​Description of the Research

The main aims of the investigations are to provide an in-depth understanding on the variables and molecular epidemiology that involve Human Papillomaviruses (HPV) infection and the disease progression. Firstly, our aim is to investigate the role of childhood HPV-infections consequences in adulthood with individuals with known HPV status from birth. Secondly, with the cervical cancer screening studies our goal is to identify better risk prediction of neoplastic transformation in high risk HPV positive women with epigenetic tests and also to evaluate screening modalities among vaccinated women for the future.

Group Members

Registered doctoral students:
Anna Jaakola, MD
Nelli Kalliomaa, BM
Laura Bergqvist, MD (Helsingin Yliopisto) 

Anna Paaso, MSc, PhD
Johanna Mäki, DDS, PhD 

Senior researchers:
Stina Syrjänen, DDS, PhD, Proffessor Emiritas
Vuokko Loimaranta, MSc, PhD, Associate Professor 

Selected Publications

Total number: 26 
1. Malagón T *, Louvanto K *, Wissing M, Burchell AN, Tellier PP, El-Zein M, Coutlée F, Franco EL. Hand-to-genital and genital-to-genital transmission of human papillomaviruses between male and female sexual partners (HITCH): a prospective cohort study. Lancet Infect Dis. 2019;S1473-3099(18)30655-8. (*co-first authors)
2. Louvanto K, Roger M, Faucher MC, Syrjänen K, Grenman S, SyrjänenS. HLA-G and vertical mother-to-child transmission of human papillomavirus infection. Hum Immunol 2018;79(6):471-476.
3. Louvanto K, Sarkola M, Rintala M, Syrjänen K, Grenman S, Syrjänen S. Breast Milk is a Potential Vehicle for HPV Transmission to Oral Mucosa of the Spouse. Pediatr Infect Dis J. 2017;36(7):627-630.
4. Louvanto K, Franco EL, Ramanakumar AV, Vasiljevic N, Scibior-Bentkowska D, Koushik A, Cuzick J, Coutlée F, Lorincz AT. Methylation of the viral and host genes in HPV-16 associated cervical lesions. Int J Cancer. 2015; 136(6):E638-45.
5. Louvanto K, Chevarie-Davis M, Ramanakumar AV, Franco EL, Ferenczy A. HPV Testing with Cytology Triage for Cervical Cancer Screening in Routine Practice. Am J Obstet Gynecol. 2014; 210(5):474.e1-7.