Novel Treatment Targets & Diagnostic Tools for Endometriosis

​​Description of research

Research project titles

  1. ​Novel Treatment Targets & Diagnostic Tools for Endometriosis
  2. Treatment of Severe Male Infertility - Prognostic Factors
  3. Characteristics of Novel Gynecological cancer marker HE4
  4. Treatment of Uterine Disorders using High Intensity Focused Ultrasound - Effect on Fertility

From our unique data base of analyzed tissue samples (clinical and 5-year follow-up data, hormone levels, gene expression arrays, proteomics, metabolomics, from endometriosis patients (n=250) and healthy controls (n=80) we will search for new targets for novel treatments. A symptom based tool is under development to estimate risk of disease and recurrence after surgery. HSD17B1 enzyme has been identified as a potential target and inhibitors are being developed and will be tested in animal models and hopefully later in humans. Prognostic factor for men going through testicular surgery to find sperm will be studied from serum and seminal
plasma (miRNA and piRNA). Preoperative testicular MRI.

Members of the research group

Kirsi Joronen, MD, PhD, postdoc (4)
Pia Suvitie, MD, specialist in Ob & Gyn, PhD student (1)
Marianne Hallamaa, MD, specialist in Ob & Gyn, PhD student (3)
Carita Edgren, MD, specialist in Ob & Gyn, PhD student (1)
Michael Gabriel, MD, PhD student (1)
Rauni Klami, MD, spec. in Ob & Gyn, PhD student (2, not registered)
Juha Mäkinen, MD, professor (1)
Päivi Rosenberg, research nurse (1,2,3,4)

Selected publications

Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen MR, Awosanya M, Suvitie P, Kujari H, Aittokallio T, Handelsman DJ, Auriola S, Perheentupa A, Poutanen M. Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions. J Clin Endocrinol Metab. 2014 Nov;99(11):E2188-97.

Huhtinen K, Desai R, Ståhle M, Salminen A, Handelsman DJ, Perheentupa A,
Poutanen M. Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels.  J Clin Endocrinol Metab. 2012 Nov;97(11):4228-35.

Hallamaa M, Suvitie P, Huhtinen K, Matomäki J, Poutanen M, Perheentupa A. Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women. Gynecol Oncol. 2012 Jun;125(3):667-72.

Suvitie PA, Hallamaa MK, Matomäki JM, Mäkinen JI, Perheentupa AH. Prevalence of Pain Symptoms Suggestive of Endometriosis Among Finnish Adolescent Girls (TEENMAPS Study).  J Pediatr Adolesc Gynecol. 2016 Apr;29(2):97-103.

Perheentupa A, Sadov S, Rönkä R, Virtanen HE, Rodprasert W, Vierula M, Jørgensen N, Skakkebæk NE, Toppari J.Semen quality improves marginally during young adulthood: a longitudinal follow-up study. Hum Reprod. 2016 Mar;31(3):502-10.