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Molecular imaging of ischemic heart disease

​​Description of research

Development of new imaging techniques based on molecular probes for ischemic heart disease. Evaluation of new imaging techniques in patients with coronary artery disease and heart failure.

Members of the research group

​Doctoral candidates:
Esa Joutsiniemi, MD
Max Kiugel, MSc
Sanna Hellberg, MSc
Mia Ståhle. MSc
Jenni Virta, MSc
Maria Grönman, MSc
Sauli Uotila, MD
Teemu Maaniitty, MD
Emilia Tuunainen, MSc

Study co-ordinator:
Heli Louhi

Selected publications

Stapel B, Kohlhaas M, Ricke-Hoch M, Haghikia A, Erschow S, Knuuti J, Silvola JM, Roivainen A, Saraste A, Nickel AG, Saar JA, Sieve I, Pietzsch S, Müller M, Bogeski I, Kappl R, Jauhiainen M, Thackeray JT, Scherr M, Bengel FM, Hagl C, Tudorache I, Bauersachs J, Maack C, Hilfiker-Kleiner D. Low STAT3 expression sensitizes to toxic effects of β-adrenergic receptor stimulation in peripartum cardiomyopathy. Eur Heart J. 2016 Mar 21.

Uusitalo V, Luotolahti M, Pietilä M, Wendelin-Saarenhovi M, Hartiala J, Saraste M, Knuuti J, Saraste A. Two- Dimensional Speckle-Tracking during Dobutamine Stress Echocardiography in the Detection of Myocardial Ischemia in Patients with Suspected Coronary Artery Disease. J Am Soc Echocardiogr. 2016 May;29(5):470-479.

Hellberg S, Silvola JM, Kiugel M, Liljenbäck H, Metsälä O, Viljanen T, Metso J, Jauhiainen M, Saukko P, Nuutila P, Ylä-Herttuala S, Knuuti J, Roivainen A, Saraste A. Type 2 diabetes enhances arterial uptake of choline in atherosclerotic mice: an imaging study with positron emission tomography tracer ¹⁸Ffluoromethylcholine.
Cardiovasc Diabetol. 2016 Feb 6;15:26.

Danad I, Uusitalo V, Kero T, Saraste A, Raijmakers PG, Lammertsma AA, Heymans MW, Kajander SA, Pietilä M, James S, Sörensen J, Knaapen P, Knuuti J. Quantitative assessment of myocardial perfusion in the detection of significant coronary artery disease: cutoff values and diagnostic accuracy of quantitative [(15)O]H2O PET imaging. J Am Coll Cardiol. 2014 Oct 7;64(14):1464-75.

Kiugel M, Dijkgraaf I, Kytö V, Helin S, Liljenbäck H, Saanijoki T, Yim CB, Oikonen V, Saukko P, Knuuti J, Roivainen A, Saraste A. Dimeric [(68)Ga]DOTA-RGD peptide targeting αvβ 3 integrin reveals extracellular matrix alterations after myocardial infarction. Mol Imaging Biol. 2014 Dec;16(6):793-801.

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 Docent Antti Saraste