Neonatal exposures, Adverse outcomes, Mucosal immunology and Intestinal microbiota (NAMI)

​​​​Description of research

The specific aims of the present research project are:

  1. Clinical study: Investigating the impact of early microbial colonization patterns on the growth of children/ obesity risk by means of well-powered prospective clinical research with long-term follow-up.
  2. Mechanism study: Characterizing foeto-maternal microbe contact.
  3. Diagnostic study: defining a microbial marker as an indicator of the risk of complicated pregnancy impacting on dysbiosis and abnormal growth in the child.
  4. Causality study: Piecing together the dilemma of deviant gut microbiota and obesity, experimental study.

Members of the research group

Professor Seppo Salminen
Docent Samuli Rautava
Docent Marko Kalliomäki
Docent Merja Nermes

post docs
MD Anna Pärtty
MD Raakel Luoto

6 doctoral students
3 research nurses (full time)

Selected publications

Rautava S, Luoto R, Salminen S, Isolauri E. Perinatal microbial contact and the origins of human disease. Nature Reviews Gastroenterology& Hepatology 2012; 9: 565-76.

Koren O, Goodrich JK, Cullender TC, Spor A, Laitinen K, Kling Bäckhed H, Gonzalez A, Werner JJ, Angenent LT, Knight R, Bäckhed F, Isolauri E, Salminen S, Ley RE. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 2012; 150: 470-80.

Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breastfeeding reduces the risk of eczema in the infant. J Allergy Clin Immunol 2012; 130: 1355-60.

Luoto R, Ruuskanen O, Waris M, Kalliomäki M, Salminen S, Isolauri E. Prebiotic and probiotic supplementation prevents human rhinovirus infections in preterm infants: a randomized, double-blind, placebocontrolled trial. J Allergy Clin Immunol 2014; 133: 405-13.

Miettinen R, Hermansson H, Merkikukka M, Gissler M, Isolauri E. Mode of delivery- impact on risk of noncommunicable diseases. J Allergy Clin Immunol 2015; 136: 1398-9.