Suomeksi
 
 
Exercise responses on non-skeletal metabolism

Description of Research:

While sedentary lifestyle is the fourth leading risk factor for global mortality, physical activity influences all cells and tissues in the body and results in impressive health benefits through your lifespan. However, it is poorly understood, how exercise training challenges metabolism and function in organs and tissues which do not take part in the skeletal muscle contraction and function such as brain, brown adipose tissue and intra-abdominal organs. Furthermore it is unclear how brain and intra-abdominal organs interact and whether training affects the interorgan crosstalk? We study the training-induced tissue-specific processes in non-skeletal tissues leading to the remission of insulin resistance using imaging methods PET, MRI and MRS.

Members of the research group: 

​Motiani Kumail MD, PhD student
Motiani Piryanka MD, PhD student
Honkala Sanna MSc, PhD student

Selected publications:

  1. Piryanka Motiani, Kirsi A. Virtanen, Kumail K. Motiani, Joonas J. Eskelinen, Roeland J. Middelbeek, Laurie J. Goodyear, Anna M. Savolainen, Jukka Kemppainen, Jørgen Jensen, Mueez U Din, Virva Saunavaara, Riitta Parkkola, Eliisa Löyttyniemi, Juhani Knuuti, Pirjo Nuutila, Kari K. Kalliokoski, Jarna C. Hannukainen. Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle aged men. Diabetes, Obesity and Metabolism 2017 Mar 20. doi: 10.1111/dom.12947.
  2. Motiani KK, Savolainen AM, Eskelinen JJ, Toivanen J, Ishizu T, Yli-Karjanmaa M, Virtanen KA, Parkkola R, Kapanen J, Grönroos TJ, Haaparanta-Solin M, Solin O, Savisto M, Ahotupa M,  Löyttyniemi E, Knuuti J, Nuutila P, Kalliokoski KK, Hannukainen JC. Two weeks of moderate intensity continuous training, but not high intensity interval training increases insulin-stimulated intestinal glucose uptake. J Appl Physiol (1985). 2017 Feb 9:jap.00431.2016. doi: 10.1152 In press.
  3. Honkala SM, Motiani KK, Eskelinen JJ, Savolainen A, Saunavaara V, Virtanen KA, Löyttyniemi E, Kapanen J, Knuuti J, Kalliokoski KK, Hannukainen JC. Exercise training reduces intrathoracic fat regardless of defective glucose tolerance. Medicine & Science in Sports & Exercise In press
  4. Hannukainen JC, Lautamäki R, Mari A, Pärkkä JP, Bucci M, Guzzardi MA, Kajander S, Tuokkola T, Knuuti J, Iozzo P. Elevated glucose oxidation, reduced insulin secretion and a fatty heart may be protective adaptions in ischemic CAD. J Clin Endocrinol Metab. 2016 Jul;101(7):2701-10. doi: 10.1210/jc.2015-4091.[IF 6.209]
  5. Hannukainen JC, Guzzardi MA, Virtanen  KA, Sanguinetti E, Nuutila P, Iozzo P. Imaging of organ metabolism in obesity and diabetes: treatment perspectives. Review. Current Pharmaceutical Design, 2014;20(39):6126-49. [IF 3.311]

 

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 Docent Jarna Hannukainen