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Allergology Research

​​​Description of research

Research project titles

  1. A Novel Glycocluster Molecule for treatment of Allergy and Cancer
  2. Mechanisms of Specific Oral Tolerance Induction (SOTI) in Food Allergic Children

The primary objective of our interdisciplinary research is to develop new glycocluster molecules to be used in microbial, allergy and cancer vaccines. The secondary object is to explore the mechanisms of action of the glycoclusters. Immunostimulatory beta-1,2-linked mannoside cluster molecules are structurally optimized and derivatized, including new covalently linked bioconjugates and fluorine-labeled targets. Advanced NMRspectroscopic methods are applied for conformational and lectin-binding studies. Immunostimulatory properties are investigated in vitro and in vivo in murine models of allergic asthma, chronic allergic inflammation and melanoma tumors. As a result, fundamental understanding relevant to application of glycobiology to immunotherapy will be achieved.

Members of the research group

Anna Koffert, MD, doctoral candidate
Kaarina Mäkinen, MD, PhD, post doc
Leena Kavén-Honka, laboratory nurse
Åbo Akademi, Organic Chemistry:
Professor Reko Leino, senior researcher
Jani Rahkila, doctoral candidate

Selected publications

Savolainen J, Ranta K, Mukherjee C, Leino R. Immunostimulatory Compounds and Uses Thereof, Finn. Pat. Appl. FI20115631 (to University of Turku and Åbo Akademi University); U.S. Pat Appl. 61/499,229 (Filed June 21, 2011); Int. Appl. PCT/FI/2012/050650 (Filed June 21, 2012); U.S. Pat. 9221861 (Issued Dec. 29,
2015).

Mukherjee C, Ranta K, Savolainen J, Leino R. Synthesis and Immunological Screening of ß-Linked Monoand Divalent Mannosides. Eur J Org Chem, 2012; 2957-2968.

Linnamaa P, Nieminen K, Koulu L, Tuomasjukka S, Kallio H, Yang B, Tahvonen R, Savolainen J. Proinflammatory and Th2 type cytokine responses in PBMC in infants are associated with parental smoking. Clin Exp Allergy, 2012;42:1472-1478.

Mukherjee C, Mäkinen K, Savolainen J, Leino R. Chemistry and biology of oligovalent β-(1,2)-linked oligomannosides: New insights into carbohydrate based adjuvants in immunotherapy. Chem-Eur J. 2013, 19:7961-74.

Rahkila J, Panchadhayee R, Ardá A, Jiménez-Barbero J, Savolainen J, Leino R. Acetylated Trivalent Mannobioses: Chemical Modification, Structural Elucidation, and Biological Evaluation. ChemMedChem. 2016;11:562-74.

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 Professor Johannes Savolainen