Advanced imaging in heart disease

​​Description of research

The research focuses on two main targets:

  1. Novel imaging techniques on ischemic heart disease and

  2. Inflammatory process in cardiac diseases.

The specific aims of the first theme are developing, testing and evaluating quantitative PET and CT angiography techniques in assessing coronary atherosclerosis and ischemia and their association with risk factors and genetic determinants.

The specific aims of the second theme are to develop and test novel diagnostic tools for inflammatory cardiac disease involving myocardial tissue, valves and arrhythmias. Inflammation has been recently linked with valvular diseases such as aortic stenosis and arrhythmias such as atrial fibrillation.

​Members of the research group

Doctoral candidates:

Valtteri Uusitalo, MD
Esa Joutsiniemi, MD
Teemu Maanitty, BM
Jussi Pärkkä, MD
Iida Soukka, BM
Haitham Ballo MD

Post docs:

Riikka Lautamäki MD, PhD
Xiang-Guo LI, PhD
Sergey Nesterov, MD, PhD
Chunlei Han, MD, PhD

Study co-ordinator:

Heli Ylikoski

Selected publications

Knuuti J, Bengel F, Bax JJ, Kaufmann PA, Le Guludec D, Perrone Filardi P, Marcassa C, Ajmone Marsan N, Achenbach S, Kitsiou A, Flotats A, Eeckhout E, Minn H, Hesse B. Risks and benefits of cardiac imaging: an analysis of risks related to imaging for coronary artery disease. Eur Heart J. 2014 Mar;3 (10):633-8.
Li XG, Helariutta K, Roivainen A, Jalkanen S, Knuuti J, Airaksinen AJ. Using 5-deoxy-5-[(18)F]fluororibose to glycosylate peptides for positron emission tomography. Nat Protoc. 2014 Jan;9(1):138-45.
Danad I, Uusitalo V, Kero T, Saraste A, Raijmakers PG, Lammertsma AA, Heymans MW, Kajander SA, Pietilä M, James S, Sörensen J, Knaapen P, Knuuti J. Quantitative Assessment of Myocardial Perfusion in the Detection of Significant Coronary Artery Disease: Cutoff Values and Diagnostic Accuracy of Quantitative [(15)O]H2O PET Imaging. J Am Coll Cardiol. 2014 Oct 7;64(14):1464-75.
Uusitalo V, Saraste A, Pietilä M, Kajander S, Bax JJ, Knuuti J. The Functional Effects of Intramural Course of Coronary Arteries and its Relation to Coronary Atherosclerosis. JACC Cardiovasc Imaging. 2015 Jun;8(6):697- 704.
Silvola JM, Virtanen H, Siitonen R, Hellberg S, Liljenbäck H, Metsälä O, Ståhle M, Saanijoki T, Käkelä M, Hakovirta H, Ylä-Herttuala S, Saukko P, Jauhiainen M, Veres TZ, Jalkanen S, Knuuti J, Saraste A, Roivainen A. Leukocyte trafficking-associated vascular adhesion protein 1 is expressed and functionally active in atherosclerotic plaques. Sci Rep. 2016 Oct 12;6:35089.

 Prof. Juhani Knuuti