Cardiovascular and metabolic effects of high-intensity interval training

​Description of research

Acute and chronic effects of exercise on human physiology studied using Positron Emission Tomography

The aim of my research is to explore the physiological effects and health benefits of acute and chronic effects of exercise on different tissues in human body. I am specifically interested on

  • The effects of high-intensity interval training on skeletal muscle and myocardial metabolism

  • The effects of acute exercise on skeletal muscle and myocardial blood flow and its regulation

  • Endogenous opioids -mediated reward in the brain after exercise in health and disease

Members of the research group

Registered doctoral candidates
Joonas Eskelinen, MD
Tanja Sjöros, MSc

Selected publications

Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Nigro P, Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY, Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ. TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nature Metabolism. 1: 291-303, 2019.
Sjöros T, Saunavaara V, Löyttyniemi E, Koivumäki M, Heinonen IHA, Eskelinen JJ, Virtanen KA, Hannukainen JC, Kalliokoski KK. Intramyocellular lipid accumulation after sprint interval and moderate-intensity continuous training in healthy and diabetic subjects. Physiological Reports. 7: e13980, 2019.
Heiskanen MA, Sjöros T, Heinonen IH, Löyttyniemi E, Koivumäki M, Motiani KK, Eskelinen JJ, Virtanen K, Knuuti J, Hannukainen JC, Kalliokoski KK. Sprint interval training decreases left-ventricular glucose uptake compared to moderate-intensity continuous training in subjects with type 2 diabetes or prediabetes. Scientific Reports. 7: 10531, 2017.
Eskelinen JJ, Heinonen I, Löyttyniemi E, Hakala J, Heiskanen M, Motiani K, Virtanen K, Pärkkä J, Knuuti J, Hannukainen JC, Kalliokoski KK. Left-ventricular vascular and metabolic adaptations to high-intensity interval and moderate intensity continuous training. A randomized trial in healthy middle-aged men. Journal of Physiology 594: 7127-7140, 2016.
Heinonen I, Kudomi N, Kemppainen J, Kiviniemi A, Noponen T, Luotolahti M, Luoto P, Oikonen V, Sipila HT, Kopra J, Mononen I, Duncker DJ, Knuuti J, Kalliokoski KK. Myocardial blood flow and its transit time, oxygen utilization, and efficiency of highly endurance-trained human heart. Basic Research in Cardiology 109: 413, 2014.