Suomeksi
 
 
Chronic inflammatory bowel diseases (IBD)

​Description of research

The prevalence of IBD i.e. ulcerative colitis and Crohn's disease has significantly increased. The aim of PETMERI project is to develope a noninvasive method to diagnose IBD. PET-MRI could replace a portion on
colonoscopies, which is nowadays the principal method to diagnose IBD.

The other project is aimed to evaluate the role of microbiome of the large bowel in the pathognesis of IBD. Cytoceratins are structural proteins of the bowel mucosa, We examine the damages of these bowel cytoceratins that are related to IBD. The fourth project examines the impact of IBD on the health and the quality of life of IBD patients as well as the economic burden of IBD.

The aim of these projects is to examine the pathogenesis and pathophysiology of IBD and to develope a new modality for diagnosing IBD. One further aim is to evaluate the impact of IBD on the patients' life.

Research projects

  • PET-MRI in the diagnostics of IBD
  • The role of microbiome in the pathogenesis of IBD
  • Cytokeratins of the mucosa of the large bowel in IBD
  • The health and economic burden of IBD

Members of the research group

Mervi Tenhami, MD; Saila Kauhanen, MD, PhD; professor Hannu Aronen
Matti Artosalo,MD; Eveliina Munukka PhD; professor Erkki Eerola; Teppo Stenholm MD, PhD
Terhi Helenius,PhD; Diana Toivola, docent; Markku Kallajoki, docent
Anssi Mustonen, MD, PhD; Kalle Mattila, MD,PhD; professor Risto Tuominen

Selected publications

Aarnio MT, Böhm JP, Nuorva KP, Pitkänen RI, Kuopio TH, Voutilainen ME.Absence of cytomegalovirus from the gastrointestinal tract of patients with active Crohn's disease. In Vivo. 2012 Jan;26(1):151-5. IF 0,974
 
Höckerstedt K, Ashorn M, Heikkinen M, Karvonen A-L, Koskenpato J, Laukkala T, Niemelä S, Rasmussen M, Scheinin T, Sipilä R, Voutilainen M. Ylävatsavaivaisen potilaan tutkiminen ja hoito. Käypä hoito-suositus. Duodecim 2012. Current care summary: Dyspepsia. In Finnish. IF not available.
 
Kellokumpu I, Voutilainen M, Haglund C, Färkkilä M, Roberts PJ, Kautiainen H. Short-term and 10-year outcome and quality of life after laparoscopic Nissen fundoplication. World J Gastroenterol 2013; 19:3810 -8. IF 2.369
 
Voutilainen M. Refluksitauti – hyvänlaatuinen mutta kallis sairaus. Lääketieteellinen aikakauskirja Duodecim 2014;130:801-7
 
Voutilainen M. Pitäisikö maksasolusyöpää seuloa Suomessa? Duodecim 2016;132:1433-8
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