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Adipose-Brain-Gut-Pancreas Interaction in Obesity and type 2 Diabetes

​​Description of research

​The overall objective of this theme is to test mechanistic hypotheses of effects of interventions on metabolic diseases using molecular imaging. We will characterize the key molecular mechanisms involved in pathogenesis of insulin resistance (IR) and in obesity and type 2 diabetes, with the final goal to identify novel therapeutic targets. We will study healthy volunteers and obese subjects with or without type 2 diabetes and use complementary animal models.

Members of the research group

Doctoral candicates

Aino Hyypiä
Eleni Rebelos
Heidi Immonen
Jaakko Mäkinen
Laura Pekkarinen
Miikka Honka
Minna Lahesmaa
Prince Dadson
Sanna Laurila
Tam Pham
Tatu Kantonen
Jukka Koffert
Milja Holstila
Mueez U Din
Sanna Honkala

Post docs

Marco Bucci
Kirsi Mikkola

Study nurse
Mia Koutu

Selected publications

Orava J, Nuutila P. .. . Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin. Cell Metab. 2011 Aug 3;14(2):272-9. [13.668]

Lidell ME, .. Nuutila P.. Evidence for Two Types of Brown Adipose Tissue in Humans. Nature Medicine, Nat Med. 2013 May;19(5):631-4. [22.462]

Lahesmaa M,.. Nuutila P. Hyperthyroidism increases brown fat metabolism in humans. J Clin Endocrinol Metab. 2014 Jan;99(1):E28-35.

Mäkinen J, .. Nuutila P. Obesity-associated intestinal insulin resistance is ameliorated after bariatric surgery.Diabetologia. 2015 May;58(5):1055-62.

Karlsson HK, .. Nuutila P, Nummenmaa L. Weight loss after bariatric surgery normalizes brain opioid receptors in morbid obesity.Mol Psychiatry. 2016 Aug;21(8):1057-62.

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 Professor Pirjo Nuutila