Bacterial Signalling Molecules in Immune Response Regulation and Biofilm Eradication/ Exploring the Role of Nrf2/ARE Pathway in Periodontitis

​Description of Research

Bacterial Signalling Molecules in Immune Response Regulation and Biofilm Eradication: With the aid of bacterial messenger molecule analogs, it is possible to activate host innate- and immune responses and epithelial integrity in a dose that is relevant to inhibit bacterial virulence mechanisms.

Exploring the Role of Nrf2/ARE Pathway in Periodontitis: The Nrf2 pathway plays a dominative role in redox homeostasis and in defence mechanisms against oxidative stress. There is a need to define the molecular mechanisms of the Nrf2/ARE pathway under physiological and pathological conditions and highlight the protective role of this pathway in periodontitis.

Members of the research group:

Gökhan Kasnak, DDS, PhD
Fares Zeidan-Chulia, MSc, PhD student
Dareen Fteita, DDS, PhD student
Samira Elmanfi, DDS

Selected publications:

Gürsoy UK, Gürsoy M, Könönen E, Sintim HO. Cyclic Dinucleotides in Oral Bacteria and in Oral Biofilms. Front Cell Infect Microbiol. 2017 Jun 21;7:273.
doi: 10.3389/fcimb.2017.00273. eCollection 2017.

Fteita D, Musrati AA, Könönen E, Ma X, Gürsoy M, Peurla M, Söderling E, Sintim HO, Gürsoy UK. Dipeptidyl peptidase IV and quorum sensing signaling in biofilm-related virulence of Prevotella aurantiaca. Anaerobe. 2017 Aug 15;48:152-159. doi: 10.1016/j.anaerobe.2017.08.009.

Zeidán-Chuliá F, Gürsoy M, Neves de Oliveira BH, Özdemir V, Könönen E, Gürsoy UK. A Systems Biology Approach to Reveal Putative Host-Derived Biomarkers of Periodontitis by Network Topology Characterization of MMP-REDOX/NO and Apoptosis Integrated Pathways. Front Cell Infect Microbiol. 2016 Jan 11;5:102. doi: 10.3389/fcimb.2015.00102.

Sintim HO, Gürsoy UK. Biofilms as "Connectors" for Oral and Systems Medicine: A New Opportunity for Biomarkers, Molecular Targets, and Bacterial Eradication. OMICS. 2016 Jan;20(1):3-11. doi: 10.1089/omi.2015.0146.

Gürsoy UK, Zeidán-Chuliá F, Yilmaz D, Özdemir V, Mäki-Petäys J, Neves de Oliveira BH, Firatli Y, Güncü GN, Caglayan F, Könönen E. Analyses of Gingival Adhesion Molecules in Periodontitis: Theoretical In Silico, Comparative In Vivo, and Explanatory In Vitro Models. J Periodontol. 2016 Feb;87(2):193-202. doi: 10.1902/jop.2015.150361.

Yılmaz D, Güncü GN, Könönen E, Barış E, Çağlayan F, Gursoy UK. Overexpressions of hBD-2, hBD-3, and hCAP18/LL-37 in Gingiva of Diabetics with Periodontitis. Immunobiology. 2015 Nov;220(11):1219-26. doi: 10.1016/j.imbio.2015.06.013.

Whole list of publications can be found:


 Docent Ulvi Kahraman Gursoy

Ulvi Kahraman Gursoy_web.jpg