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Detecting viral infections and targeting antibiotic use in children with MxA protein and other biomarkers

​Research project titles

  1. Viral and bacterial respiratory tract infections in children
  2. Detecting viral infections and targeting antibiotic use in children with MxA protein and other biomarkers

Description of research

Our research focuses on respiratory tract infections in children. We perform clinical studies on the roles of viruses and bacteria in respiratory tract infections, taking into account also the genetic susceptibility and environmental risk factors. To this aim, we continue a birth cohort follow-up study of respiratory tract infections in children. Another aim is to identify features of the host response that could be exploited in the differentiation between viral and bacterial causes of infection. We are developing and clinically evaluating new methods to rapidly identify viral and bacterial infections, in order to better target antibiotics and other treatments.

Members of the research group

Registered doctoral candidates
Sinikka Karppinen, MD
Laura Toivonen, MD
Tamara Teros-Jaakkola, MD
Linnea Schuez-Havupalo, MD
Lauri Ivaska, MD
Maria Hartiala, MD
Ruut Piri, MD

Postdoc
Elina Lahti, MD, PhD

Selected publications

Toivonen L, Schuez-Havupalo L, Karppinen S, Teros-Jaakkola T, Rulli M, Mertsola J, Waris M, Peltola V. Rhinovirus infections in the first 2 years of life. Pediatrics 2016;138:e20161309.

Toivonen L, Karppinen S, Schuez-Havupalo L, Teros-Jaakkola T, Rulli M, Mertsola J, He Q, Waris M, Peltola V. Burden of recurrent respiratory tract infections in children: a prospective cohort study. Pediatr Infect Dis J 2016 Jul 22. [Epub ahead of print].

Karppinen S, Toivonen L, Schuez-Havupalo L, Waris M, Peltola V. Interference between respiratory syncytial virus and rhinovirus in respiratory tract infections in children. Clin Microbiol Infect 2016;22:208 e1-6.

Karppinen S, Vuononvirta J, He Q, Waris M, Peltola V. Effects of rhinovirus infection on nasopharyngeal bacterial colonization in infants with wild or variant types of mannose-binding lectin and Toll-like receptors 3 and 4. J Pediatr Infect Dis Soc 2013;2:240-247.

Peltola V, Waris M, Kainulainen L, Kero J, Ruuskanen O. Virus shedding after human rhinovirus infection in children, adults and patients with hypogammaglobulinemia. Clin Microbiol Infect 2013;19:E322–E327.

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 Professor Ville Peltola