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Laboratory of Biophysics

Description of Research

Laboratory of Biophysics develops instrumentation and methods for light microscopy, correlative multimodal microscopy and bio-analysis in general. The key application areas lie broadly within life-sciences research from basic research to applications but also in industrial processes of food tech-nologies and industrial process waters are today on the agenda.
 
The group has recently developed new super-resolution techniques for 3D super resolved tomography including software, super-resolution compatible nano-probes, super-resolution compatible in-vitro model for studies in bone-biology and most recently photoacoustic microscopy methods (PAM). In 2014 one of the former group members, Stefan Hell, was awarded the Nobel Prize in Chemistry for his work in development of super-reselving microscopes, work that originated from our laboratory in the mid 90’s.
 
On the bioanalysis side the group has developed a new type of chemical fingerprinting technique that has been applied from diagnostics of oral cancer to profiling of microbiota in the gut and analysis of bacteria in urine. The same technology has been demonstrated in several applications in the food industry and the technology has found its way also to production in assessment of industrial process waters.
 
The group has been able to produce results that have lead both academic merits and into industrially exploited applications by a) licencing of the developed technologies to e.g. Leica Microsystems (2-photon microscopy, STED microscopy) and  b) through own startups (Arcdia International Oy and Aqsens Oy)

Members of the research group

Pekka Hänninen, Professor
Eija Martikkala, PhD, post-doc
Anita Rozwandowicz-Jansen, PhD post-doc
Markus Peurla, PhD post-doc, manager of the EM facility
Sami Koho, PhD, post-doc (2016), manager of the STED/AFM facility
Takahiro Deguchi, PhD, post-doc (2016)
Elnaz Fazelli, MSc, doctoral student (shared with groups of prof. J. Peltonen and prof. J. Eriksson/ÅA)
Janne Kulpakko, MSc, doctoral student
Elena Tcarenkova, MSc, doctoral student
Neeraj Prabhakar, MSc, doctoral student (shared with group of prof. Jessica Rosenholm/ÅA)
Petra Miikkulainen, MSc, doctoral student (50% coordinator of Bioimaging Masters Program)

Selected Publications

T. Deguchi, S. Koho, T. Nareoja, and P. Hanninen, “Axial Super-resolution by Mirror-reflected Stimulated Emission Depletion Microscopy,” Opt. Rev., vol. 21, pp. 389–394, 2014.
 
N. Prabhakar, T. Näreoja, E. von Haartman, D. Ş. Karaman, H. Jiang, S. Koho, T. a Dolenko, P. E. Hänninen, D. I. Vlasov, V. G. Ralchenko, S. Hosomi, I. I. Vlasov, C. Sahlgren, and J. M. Rosenholm, “Core-shell designs of photoluminescent nanodiamonds with porous silica coatings for bioimaging and drug delivery II: application.,” Nanoscale, vol. 5, no. 9, pp. 3713–3722, 2013.
 
P. E. Hänninen, J. J. Siivonen, P. I. Väisänen, S. A. Tiittanen, M. M. Lehmusto, T. Teimonen, N. Törnkvist, M. A. Sandell, A. J. Knaapila, P. Mundill, and H. J. Härmä, “Fuzzy liquid analysis by an array of nonspecifically interacting reagents: the taste of fluorescence.,” J. Am. Chem. Soc., vol. 135, no. 20, pp. 7422–7425, 2013.
 
P. Hanninen, A. Soini, N. Meltola, J. Soini, J. Soukka, and E. Soini, “A new microvolume technique for bioaffinity assays using two-photon excitation,” Nat. Biotechnol., vol. 18, pp. 548–550, 2000.
 
S. W. Hell and J. Wichmann, “Breaking the diffraction resolution limit by stimulated emission: stimulated emission depletion microscopy,” Opt. Lett., vol. 19, pp. 780–782, 1994.
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 Professor Pekka Hänninen

 
Pekka Hänninen kuva.jpg