Bone and energy metabolism

​Description of Research

Bone is increasingly recognized as a player in energy metabolism via its interactions with other tissues. Skeleton has emerged as an endocrine organ which is both capable of regulating energy metabolism as well as being a target for it. Disorders of glucose metabolism, type 1 and type 2 diabetes, are both associated with adverse skeletal effects and increased fracture risk. The pathophysiology of diabetic bone disease is still unclear and our understanding on glucose metabolism and toxicity in bone is limited compared to many other tissues.

We aim to better understand how the changes in energy metabolism affect bone cells and bone microenvironment. We are also interested in glucose utilization and metabolic phenotype of the bone cells during lineage allocation and differentiation from their progenitors. We are focusing on osteoblasts, the bone-forming cells, which produce a large amount of extracellular matrix and have high demand for both energy and building blocks. Furthermore, we are interested in osteocalcin, a bone-derived factor that appears to regulate insulin secretion and sensitivity. The uncarboxylated form of osteocalcin could provide one possible link between bone and energy metabolism.  We use cell culture and cell-based methods and work also on serum samples obtained from selected clinical cohorts.

Members of the research group

MIlja Arponen, MSc, Doctoral candidate
Tiina Kähkönen, MSc, Doctoral candidate
Suvi-Kukka Tuomi, biomedical student

Selected Publications

Kähkönen TE, Tuomela JM, Grönroos TJ, Halleen JM, Ivaska KK, Härkönen PL. Dovitinib dilactic acid reduces tumor growth and tumor-induced bone changes in an experimental breast cancer bone grwoth model. J Bone Oncol 2019, 16: 100232

Kähkönen TE, Ivaska KK, JIan M. Buki KG, Väänänen HK, Härkönen PL. Role of fibroblast growth factor receptors (FGFR) and FGFR like-1 (FGFRL1) in mesenchymal stromal cell differentiation to osteoblasts and adipocytes. Mol Cell Endocrinol. 2018, 461: 194-204.

Ivaska KK, Huovinen V, Soinio M, Hannukainen JC, Saunavaara V, Salminen P, Helmiö P, Parkkola R, Nuutila P, Kiviranta R. Changes in bone metabolism after bariatric surgery by gastric bypass and sleeve gastrectomy. Bone 2017, 95:47-54.

Huovinen V, Ivaska KK, Kiviranta R, Bucci M, Lipponen H, Sandboge S, Raiko J, Eriksson JG, Parkkola R, Iozzo P, Nuutila P. Bone mineral density is increased after a 16-week resistance training intervention in elderly women with decreased muscle strength. Eur J Endocrinol 2016, 175(6):571-582.

Ivaska KK, Heliövaara MK, Ebeling P, Bucci M, Huovinen V, Väänänen HK, Nuutila P, Koistinen HA. The effects of acute hyperinsulinemia on bone metabolism. Endocr Connect. 2015;4(3):155-62.

Viljakainen H, Ivaska KK, Paldánius P, Lipsanen-Nyman M, Saukkonen T, Pietiläinen KH, Andersson S, Laitinen K, Mäkitie O. Suppressed bone turnover in obesity: a link to energy metabolism? A case-control study. J Clin Endocrinol Metab. 2014;99(6):2155-63.


 Docent Kaisa Ivaska

Ivaska Kaisa.jpg