RNA- or trauma -mediated gene regulation

​Description of Research

Our research focuses on the mechanisms involved in short regulatory RNA physiology. These molecules (siRNAs, shRNAs, microRNAs) modulate gene expression, thus affecting not only differentiation and developmental maturation of cells and organ systems, but also tissue healing after trauma. We aim to understand, how differentiation of individual cell types could experimentally be regulated. We are also interested in learning how miRNAs are involved in tissue healing after trauma.

In the BAAC study (Biological Assessment of Acute Concussions) we study the use of mi-croRNA and metabolomics assays in the evaluation of contact sport –induced concussions in athletes.

In the Entesophyte project we study the causes and consequences of calcific spur formation at the Achilles tendon - bone insertion

In the EUROCLAST project we study the extensive vesicular trafficking in bone-resorbing osteoclasts


Members of the research group

Graduate students:
Matthieu Bourgery, MSc
Arjen Gebraad, MSc
Kristian Johansson, MD
Jussi Mäkilä, MSc, Med. student

Undergraduate students:
Panu Räty, Med.student
Ulla Rahijärvi, Biomed. student
pt students: Emilia Eklund, Teemu Hantunen, Mikko Larinmaa, Jenna Laukkarinen, Noora Mustonen,  Anna Mäkitalo, Marika Nummela, Tiina Puijola, Jenny Silvennoinen, Katriina Toivonen, Mikko Tulonen

Selected Publications

Johansson KJ, Sarimo JJ, Lempainen LL, Laitala-Leinonen T, Orava SY (2013) Calcific spurs at the insertion of the Achilles tendon: a clinical and histological study. Muscles Ligaments Tendons J. 2(4):273-277.

Kiviniemi A, Mäkelä J, Mäkilä J, Saanijoki T, Liljenbäck H, Poijärvi-Virta P, Lönn-berg H, Laitala-Leinonen T, Roivainen A, Virta P (2012) Solid-supported NOTA and DOTA chelators useful for the synthesis of 3'-radiometalated oligonucleotides. Bio-conjug Chem. 23(9):1981-1988.

Laine SK, Alm JJ, Virtanen SP, Aro HT, Laitala-Leinonen TK (2012) MicroRNAs miR-96, miR-124, and miR-199a regulate gene expression in human bone marrow-derived mesenchymal stem cells. J Cell Biochem. 113(8):2687-2695.

Heinonen J, Taipaleenmäki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Järvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Säämänen AM (2011) Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthritis Cartilage 19(8):1026-1035.

Nurmio M, Joki H, Kallio J, Määttä JA, Väänänen HK, Toppari J, Jahnukainen K, Laitala-Leinonen T (2011) Receptor tyrosine kinase inhibition causes simultaneous bone loss and excess bone formation within growing bone in rats. Toxicol Appl Pharmacol. 254(3):267-279.


 Docent Tiina Laitala-Leinonen