Molecular mechanisms of cell trafficking

​Description of Research

Lymphatic and vascular endothelium plays a pivotal role in leukocyte and cancer cell migration by expressing counter-receptors for the cell-surface molecules on the migrating cells that mediate trafficking. One of these molecules is Common Lymphatic Endothelial and Vascular Endothelial Receptor-1 (CLEVER-1). We have generated both constitutive and conditional gene manipulated models for CLEVER-1 and studied its functional role in various disease processes.

Additionally, we have used phage display to identify leukocyte and tumor cell expressed ligands for CLEVER-1. Other cell-surface molecules under investigation are PV1 and the ectoenzymes AOC3 (VAP-1)  and CD73. 

We also aim at identifying new cell-surface molecules on lymphatic endothelium to study their participation in cell trafficking by using gene manipulated disease models, RNAi and global gene expression analysis. We collaborate closely with the research group of Professor Marko Salmi.

Members of the research group

MD Sam Kaitaniemi, doctoral candidate
MB Sanni-Lotta Aaltonen
Maritta Pohjansalo, technician

Selected Publications

Rantakari P*, Jäppinen N*, Lokka E, Mokkala E, Gerke H, Peuhu E, Ivaska J, Elima K, Auvinen K, Salmi M. Fetal liver endothelium regulates the seeding of tissue-resident macrophages. Nature 2016, 538(7625):392- 396. *Equal contribution

E-Khuda I, Fair-Mäkelä R, Kukkonen-Macchi A, Elima K, Karikoski M, Rantakari P, Miyasaka M, Salmi M, Jalkanen S. Gene expression profiling of afferent and efferent lymphatics leads to identification of new candidates for targeted manipulation of cell traffic in lymph nodes. Proc Natl Acad Sci 2016, 113(38):10643-8.

Palani S, Elima K, Ekholm E, Maksimow M, Jalkanen S, Salmi M. Monocyte Stabilin-1 suppresses the activation of Th1 lymphocytes. J Immunol 2016, 96(1):115-23.

Karikoski M*, Marttila-Ichihara F*, Elima K, Rantakari P, Hollmén M, Kelkka T, Gerke H, Huovinen V, Irjala H, Holmdahl R, Salmi M, Jalkanen S. Clever-1/Stabilin-1 controls cancer growth and metastasis. *Equal contribution. Clin Cancer Res 2014, 20(24):6452-64.

Kaitaniemi S, Grön K, Elovaara H, Salmi M, Jalkanen S, Elima K. Functions of Vascular Adhesion Protein-1 are modulated by a novel splice variant. PLoS ONE 2013, 8(1): e54151.