Local and systemic regulation of skeletal tissue development and homeostasis by miRNAs and other factors

​Description of Research

The aim of the research is to find and characterize novel factors that regulate skeletal tissue deve-lopment and homeostasis, with the ultimate goal to find regulatory factors and conditions that facili-tate development of mesenchymal stem cell based transplantation therapies and/or find biomarkers that can be used for monitoring of trauma-related skeletal tissue healing.

Genome wide approaches have been used to search for novel  factors regulating limb chondrogenesis, endochondral ossification and fracture healing. Recently we have focused on the microRNAs in the local and systemic regulation of  mesenchymal stromal cell differentiation and tissue homeostasis.

List of Personnel

Jussi Heinonen
Erika Ekholm
Katja Fagerlund
Sanna Honkala
Merja Lakkisto

Selected Publications

Taipaleenmäki H, Harkness L, Chen L, Larsen KH, Säämänen AM, Kassem M, Abdallah BM. The crosstalk between transforming growth factor-β1 and delta like-1 mediates early chondrogenesis during embryonic endochondral ossification. Stem Cells. 2012 Feb;30(2):304-13.

Chen L, Qanie D, Jafari A, Taipaleenmaki H, Jensen CH, Säämänen AM, Sanz ML, Laborda J, Abdallah BM, Kassem M. Delta-like 1/fetal antigen-1 (Dlk1/FA1) is a novel regulator of chondrogenic cell differentiation via inhibition of the Akt kinase-dependent pathway. J Biol Chem. 2011 Sep 16;286(37):32140-9. doi: 10.1074/jbc.M111.230110. Epub 2011 Jul 1.

Heinonen J, Taipaleenmäki H, Roering P, Takatalo M, Harkness L, Sandholm J, Uusitalo-Järvinen H, Kassem M, Kiviranta I, Laitala-Leinonen T, Säämänen AM. Snorc is a novel cartilage specific small membrane proteoglycan expressed in differentiating and articular chondrocytes. Osteoarthritis Car-tilage. 2011 Aug;19(8):1026-35. doi: 10.1016/j.joca.2011.04.016. Epub 2011 May 17.

Taipaleenmäki H, Abdallah BM, AlDahmash A, Säämänen AM, Kassem M. Wnt signalling mediates the cross-talk between bone marrow derived pre-adipocytic and pre-osteoblastic cell populations. Exp Cell Res. 2011 Apr 1;317(6):745-56. doi: 10.1016/j.yexcr.2010.12.015. Epub 2011 Jan 4.

Salminen H, Vuorio E, Säämänen AM. Expression of Sox9 and type IIA procollagen during attempted repair of articular cartilage damage in a transgenic mouse model of osteoarthritis. Arthritis Rheum. 2001 Apr;44(4):947-55.