Intestinal microbiology/Antibacterial effects of nanostructures

Description of Research

Gastrointestinal tract is the major surface for microbial colonization in the human body. Gut microbiota dysbiosis has been linked to several health-related conditions and it seems that the overall balance in the composition of gut bacteria and the presence of certain bacterial species is crucial for maintaining human health. The aim of our study group is to investigate the clinical role of gut microbiota in certain clinical conditions by studying both the composition and the metabolic capabilities of the gut bacteria.

Scientific Aims

  • Ecology of intestinal microbiota, normal microbiota and connections to clinical diseases
  • Development of microbiological identification methods
  • NGS, infection diagnosis
  • Antibactyerial effects of nanostructures

List of Personnel

Eveliina Munukka, PhD, senior researcher
Anniina Rintala, MS, reg doct candidate
Marianne Gunell, PhD, senior researcher

Selected Publications

Ahtinen H, Kulkova J, Lindholm L, Eerola E, Hakanen AJ, Moritz N, Söderström M, Saanijoki T, Jalkanen S, Roivainen A, Aro HT. (68) Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections .EJNMMI Res.4:45. (2014 Aug 8).

Spina A, Kerr KG, Cormican M, Barbut F, Eigentler A, Zerva L, Tassios P,
Popescu GA, Rafila A, Eerola E, Batista J, Maass M, Aschbacher R, Olsen KE,
Allerberger F. Spectrum of enteropathogens detected by the FilmArray GI Panel in
a multicentre study of community-acquired gastroenteritis. Clin Microbiol Infect.
2015 Apr 20. [Epub ahead of print] Review.

Rintala A, Munukka E, Weintraub A, Ullberg M, Eerola E. Evaluation of a
multiplex real-time PCR kit Amplidiag® Bacterial GE in the detection of bacterial
pathogens from stool samples. J Microbiol Methods. 2016 128:61-5.

Mokkala K, Röytiö H, Munukka E, Pietilä S, Ekblad U, Rönnemaa T, Eerola E,
Laiho A, Laitinen K. Gut Microbiota Richness and Composition and Dietary Intake
of Overweight Pregnant Women Are Related to Serum Zonulin Concentration, a Marker for Intestinal Permeability. J Nutr. 2016: 146(9):1694-700.

Rintala A, Pietilä S, Munukka E, Eerola E, Pursiheimo JP, Laiho A, Pekkala S, Huovinen P. (2917) Gut Microbiota Analysis Results Are Highly Dependent on the 16S rRNA Gene Target Region, Whereas the Impact of DNA Extraction Is Minor. J Biomol Tech. ;28(1):19-30.