Lyme borreliosis: a comprehensive approach

Description of Research

The project focuses on Lyme borreliosis (LB) and other tick borne infections and addresses the following questions: Prevalence of ticks and epidemiology of LB and other borrelioses in Finland. Susceptibility of humans to disseminated LB. Pathogenesis of LB including dissemination of LB to the different target organs, the role of borrelia adhesins in this process, and the molecular mechanisms of tissue tropism of borrelia. Molecular and cellular events in the pathogenesis of Lyme neuroborreliosis. Development of novel diagnostics for LB and other borrelioses (e.g. Borrelia miyamotoi infection), including identification of novel biomarkers. Development of PET/CT imaging of LB.

Members of the research group

PhD Jemiina Salo
MSc Julia Honkasalo
MD Elisa Kortela
MSc Maija Laaksonen
MSc Annukka Pietikäinen
MD Eeva Sajanti
Graduate student Otto Glader
Graduate student Julia Rask
Technician Tuula Rantasalo

Selected publications

Kortela E., Hytönen J., Numminen J., Overmyer H., Saxen H., Oksi J.: Cerebral vasculitis and intracranial multiple aneurysms in a child with Lyme neuroborreliosis. JMM Case reports, in press.

Laaksonen M., Sajanti E., Sormunen J., Penttinen R., Hänninen J., Ruohomäki K., Sääksjärvi I., Vesterinen E., Vuorinen I., Hytönen J., Klemola T.: Crowdsourcing based nationwide tick collection reveals the distribution of Ixodes ricinus and I. persulcatus and associated pathogens in Finland. Emerging Microbes & Infections, in press.

Pietikäinen A., Siitonen R., Liljenbäck H., Söderström M., Roivainen A., Hytönen J.: In vivo imaging of Lyme arthritis in mice by [18F]-fluorodeoxyglucose positron emission tomography/computed tomography. Scandinavian Journal of Rheumatology, in press.

Hytönen J., Khawaja T., Grönroos J.O., Jalava A., Meri S., Oksi J.: Louse-borne relapsing fever in Finland in two asylum seekers from Somalia. APMIS, (2017) Jan;125(1):59-62.

Pietikäinen A., Maximow M., Kauko T., Hurme S., Salmi M., Hytönen J.: Cerebrospinal fluid cytokines in Lyme neuroborreliosis. J Neuroinflammation (2016) Oct 18;13(1):273.

Salo J., Pietikäinen A., Söderström M., Auvinen K., Salmi M., Ebady R., Moriarty TJ., Viljanen MK., and Hytönen J.: Flow tolerant adhesion of a bacterial pathogen to human endothelial cells through interaction with biglycan. J Infect Dis (2016), 15;213(10):1623-31.

Salo J., Jaatinen A., Söderström M., Viljanen M.K., Hytönen J.: Decorin Binding Proteins of Borrelia burgdorferi Promote Arthritis Development and Joint Specific Post-Treatment DNA Persistence in Mice. PLoS One (2015) Mar 27;10(3).

Sajanti E., Gröndahl-Yli-Hannuksela K., Kauko T., He Q., Hytönen J.: Lyme borreliosis and deficient mannose binding lectin pathway of complement. J Immunol (2015) 194: 358–363.

Hytönen J., Kortela E, Waris M., Puustinen J., Salo J., Oksi J.: CXCL13 and neopterin concentrations in cerebrospinal fluid of patients with Lyme neuroborreliosis and other diseases that cause neuroinflammation. J Neuroinflammation (2014) 11:103.

Salo J., Loimaranta V., Lahdenne P., Viljanen M.K., Hytönen J.: Decorin binding by DbpA and B of Borrelia garinii, Borrelia afzelii and Borrelia burgdorferi s.s. J Infect Dis (2011), 204, 65-73.



 MD, PhD Jukka Hytönen

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