Speaker: Florian Freudenberg, Translational Psychiatry Laboratory, Department of Psychiatry, Frankfurt University Hospital

Title: "Targeted disruption of NOS-I PDZ interactions using viral gene transfer: Implications for psychiatric disorders"

Time: Tue 28.11 at 13:15

Location: PET centre seminar room

Host: Michael Courtney

Florian Freudenberg is a research group leader in the Laboratory of Translational Psychiatry at the Department of Psychiatry, Psychosomatic Medicine and Psychotherapy of the University Hospital Frankfurt (Germany). His group studies the molecular mechanisms involved in the pathophysiology of mental disorderswith a particular emphasis on synaptic protein interactions relevant to schizophrenia and mood disorders. In order to achieve this, his group utilizes a wide range of methods, including behavioral and molecular phenotyping of mice, in vitro and in vivo viral gene transfer, and morphological and histological analyses. His current main line of research revolves around the interaction of neuronal nitric oxide synthase (nNOS) with its adaptor protein NOS1AP in schizophrenia, which his group was able to connect to different schizophrenia-related (endo)phenotypes.​