Suomeksi
 
 
Imaging of neuroinflammation - focus on microglia
Laura Airas_PIC.jpg
Laura Airas, MD, PhD, Division of clinical neurosciences, Turku University Hospital, Turku, Finland
Juha Rinne, Professor, Turku PET-center
Merja Haaparanta-Solin, Professor, Turku PET center

GOAL:
To elucidate the pathogenic mechanisms leading to neurodegeneration in multiple sclerosis (MS) in order to improve treatment of progressive MS.
 
GROUP MEMBERS:
  • Susanne Vainio, MSc
  • Joni Merisaari
  • Eero Rissanen, MD
  • Marcus Sucksdorff, MD
  • Jouni Tuisku
  • Teemu Paavilainen, MD, PhD

COLLABORATORS:
  • Daniel Anthony, Professor, University of Oxford, UK
  • Trevor Owens, Professor, University of Southern Denmark, Denmark
  • Bente Finsen, Professor, University of Southern Denmark, Denmark
  • David Hafler, Professor, Yale University, USA
  • Richard Carson, Professor, Yale University, USA
  • Ming-Kai Chen, Associate Professor, Yale University, USA
 
SELECTED PUBLICATIONS:
  1. Mills J, Thompson L, Mueller C, Waickman A, Jalkanen S, Niemela J, Airas L and Bynoe M. CD73 is required for efficient entry of lymphocytes into thecentral nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci. 2008; Jul 8;105(27):9325-3
  2. Niemelä J, Ifergan I, Yegutkin, G, Jalkanen S, Prat A and Airas L. Interferon-β regulates CD73 and adenosine expression at the blood-brain-barrier. Eur. J. Immunol. 2008; Oct;38(10):2718-26
  3. Rissanen E, Virta J, Paavilainen T, Tuisku J, Helin S, Luoto P, Parkkola R, Rinne JO, Airas L. Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: a [11C]TMSX Brain PET study. JCBFM. 2013;1394-401.
  4. Dickens AM, Vainio S, Marjamäki P, Johansson J, Lehtiniemi P, Rokka J, Rinne J, Solin O, Haaparanta-Solin M, Jones P, Trigg W, Anthony DC, Airas L.Detection of microglial activation in an acute model of neuroinflammation using positron emission tomography and radiotracers [11C]-(R)-PK11195 and[18F]GE-180. JNM. 2014;55(3):466-72
  5. Rissanen E, Tuisku J, Rokka J, Paavilainen T, Parkkola R, Rinne JO and Airas L. In vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using Positron Emission Tomography Imaging and Radioligand [11C]PK11195. JNM. 2014;55(6):939-944
Publications:
60 and those with (IF>5): 22
Amount of funding : 600 000 €


Full list  of publications in PDF List of publications Airas L 23 9 2016.pdfList of publications Airas L 23 9 2016.pdf

 

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