Anesthesia Mechanisms
harry scheinin_PIC1.jpg
Harry Scheinin
, Adjunct Professor, Turku PET Centre, University of Turku

We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia.


Senior researchers

   Kaike Kaisti
   Kimmo Kaskinoro
   Timo Laitio
   Jaakko Långsjö
   Anu Maksimow
Graduate students:
   Oskari Kantonen
   Lauri Laaksonen
   Linda Radek
   Annalotta Scheinin
Undergraduate students:
   Jarno Korhonen
   Aleksi Nummela
   Aleksi Palola


   Michael Alkire, University of California, Irvine, USA
   Anthony Hudetz, University of Michigan, USA
   George Mashour, University of Michigan, USA
   Lauri Nummenmaa, University of Turku and Aalto University
   Antti Revonsuo, University of Turku, Turku Finland and University of Skövde, Skövde, Sweden
   Mika Scheinin, University of Turku, Turku, Finland


1.    Långsjö JW, Revonsuo A, Scheinin H. Harnessing anesthesia and brain imaging for the study of human consciousness. Curr Pharm Des 2014;20:4211-4224.

2.    Maksimow A,  Silfverhuth M, Långsjö J, Kaskinoro K, Georgiadis S, Jääskeläinen S, Scheinin H. Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol. PLoS ONE 2014 Nov 24;9(11):e113616. doi: 10.1371/journal.pone.0113616. eCollection 2014.

3.    Långsjö JW, Alkire MT, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H.Returning from oblivion: imaging the neural core of consciousness; J Neurosci 2012;32:4935-4943.

4.    Kaisti KK, Långsjö JW, Aalto S, Oikonen V, Sipilä H, Teräs M, Hinkka S, Metsähonkala L, Scheinin H. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003;99:603-613.

5.    Kaisti KK, Metsähonkala L, Teräs M, Oikonen V, Aalto S, Jääskelainen S, Hinkka S, Scheinin H. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 2002;96:1358-1370


1. Henri Pesonen, Roosa E. Kallionpää, Annalotta Scheinin, Nils Sandman, Ruut Laitio, Harry Scheinin, Antti Revonsuo and Katja Valli "A novel Bayesian linear regression model for analysing event-related potentials"



PUBLICATIONS 2011-2015 (ALL/IF>5):

External funding:
·         Academy of Finland
·         Jane and Aatos Erkko Foundation
2013-2018:  € 1.600.000;-, 2016 € 420.000;-

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