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Novel PET Radiopharmaceuticals for Diagnostic Imaging of Alzheimer’s disease

 Merja_Haaparanta-Solin.jpg
Merja Haaparanta-Solin, Ph.D, Professor (Preclinical imaging)

Juha Rinne, M.D., Ph.D, Professor (Neuroresearch)

Olof Solin, Ph.D, Professor (Radiochemistry)

 
GOAL:
The purpose of this project is to study normal ageing, cognitive brain functions and the etiology and pathophysiology and treatment of neurodegenerative diseases. Of the neurodegenerative diseases the main focus is on Alzheimer’s disease.
Our program on the development of biological probes is focused on the design, synthesis and validation of positron-emitting tracers for Alzheimer’s disease PET imaging. General aims of the group are the development of specific in vivo probes for β-amyloid plaques for early detection of Alzheimer's disease and the design of PET/pre-clinical methods in the development of in vivo non-invasive procedures to quantitate pharmacokinetics in experimental animals.
 
GROUP MEMBERS:
Postdoc:
  • Francisco Lopez-Picon, PhD
  • Rea Pihlaja, PhD
Graduate students:
  • Anniina Snellman MSc
  • Johanna Rokka MSc
  • Jatta Takkinen MSc
  • Susanne Vainio MSc
  • Jenni Vasara MSc
 
SELECTED PUBLICATIONS:
  1. Nordberg A, Rinne JO, Kadir A, Långström B. The use of PET in Alzheimer disease. Nat Rev Neurol. 2010, 6:78-87.
  2. Virta JJ, Aalto S, Järvenpää T, Karrasch M, Kaprio J, Koskenvuo M, Räihä I, Viljanen T, Rinne JO. Voxel-based analysis of cerebral glucose metabolism in mono- and dizygotic twins discordant for Alzheimer disease. J Neurol Neurosurg Psychiatry. 2009, 80: 259-66.
  3. Teare H, Robins E G., Kirjavainen A, Forsback S, Sandford G, Solin O, Luthra S K., Gouverneur V. Radiosynthesis and Evaluation of [18F]Selectfluor bis(triflate). Angewandte Chemie International Edition, Published online August 2010
  4. Koivunen J, Verkkoniemi A, Aalto S, Paetau A, Ahonen JP, Viitanen M, Någren K, Rokka J, Haaparanta M, Kalimo H, Rinne JO. PET amyloid ligand [11C]PIB uptake shows predominantly striatal increase in variant Alzheimer's disease. Brain. 2008, 131:1845-53.
  5. N Kemppainen, S Aalto, I Wilson, K Någren, S Helin, A Brück, V Oikonen, M Kailajärvi, M Scheinin, M Viitanen, R Parkkola, JO Rinne. Voxel Based Analysis of Amyloid Ligand [11C]PIB Uptake in Alzheimer’s Disease. Neurology 2006, 67: 1575-80.
 
Total number of publications in 2005-2010: 93
The number of PhD degrees completed in 2005-2010: 10
 
External funding of the research group in 2005-2010 (total amount) and in 2009 separately: 1 M € (total), 290000 € (2009)
 
 
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