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Imaging of neuroinflammation - focus on microglia

Laura Airas_PIC.jpg
Laura Airas, Professor, Division of clinical neurosciences, Turku University Hospital and University of Turku Turku

GOAL
To elucidate the pathogenic mechanisms leading to neurodegeneration in multiple sclerosis (MS) in order to improve treatment of progressive MS.
 
GROUP MEMBERS
  • Eero Rissanen, MD, PhD
  • Heidi Högel, MSc, PhD
  • Marcus Sucksdorff, MD
  • Jouni Tuisku, MSc
  • Susanne Vainio, MSc
  • Maija Saraste, MSc
  • Sini Laaksonen, MD
  • Anna Vuorimaa, Medical student
  • Imran Waggan, BSc
  • Svetlana Bezukladova, B.E.
  • Marjo Nylund, Coordinator
COLLABORATORS
  • Juha Rinne, Professor, Turku PET center​
  • Merja Haaparanta-Solin, Professor, Turku PET center
  • Veijo Hukkanen, MD, PhD, 
  • Francisco López Picón, PhD, University of Turku
  • Sirpa Jalkanen, Professor, University of Turku
  • Anne Roivainen, PhD, Turku PET center
  • Teemu Paavilainen, MD, PhD, University of Turku
  • Riitta Parkkola, Professor, University of Turku
  • Daniel Anthony, Professor, University of Oxford, UK
  • Trevor Owens, Professor, University of Southern Denmark, Denmark
  • Bente Finsen, Professor, University of Southern Denmark, Denmark
  • David Hafler, Professor, Yale University, USA
  • Richard Carson, Professor, Yale University, USA
  • Ming-Kai Chen, Associate Professor, Yale University, USA
  • Jens Kuhle, MD, PhD, University Hospital Basel, Switzerland
  • David Pitt, MD, PhD, Yale University, USA
  • Richard Nicholas MD, PhD, Imperial College, London
  • Bruno Stankoff, MD, PhD, Hospital de Salpetriere, Paris
  • Alexander Gerhard, University of Mancherster, UK 
SELECTED PUBLICATIONS
  1. Mills J, Thompson L, Mueller C, Waickman A, Jalkanen S, Niemela J, Airas L and Bynoe M. CD73 is required for efficient entry of lymphocytes into thecentral nervous system during experimental autoimmune encephalomyelitis. Proc Natl Acad Sci. 2008; Jul 8;105(27):9325-3
  2. ​Rissanen E, Virta J, Paavilainen T, Tuisku J, Helin S, Luoto P, Parkkola R, Rinne JO, Airas L. Adenosine A2A Receptors in Secondary Progressive Multiple Sclerosis: a [11C]TMSX Brain PET study. JCBFM. 2013;1394-401.​
  3. Dickens AM, Vainio S, Marjamäki P, Johansson J, Lehtiniemi P, Rokka J, Rinne J, Solin O, Haaparanta-Solin M, Jones P, Trigg W, Anthony DC, Airas L.Detection of microglial activation in an acute model of neuroinflammation using positron emission tomography and radiotracers [11C]-(R)-PK11195 and[18F]GE-180. JNM. 2014;55(3):466-72
  4. Rissanen E, Tuisku J, Rokka J, Paavilainen T, Parkkola R, Rinne JO and Airas L. In vivo Detection of Diffuse Inflammation in Secondary Progressive Multiple Sclerosis Using Positron Emission Tomography Imaging and Radioligand [11C]PK11195. JNM. 2014;55(6):939-944
  5. Sucksdorff M, Rissanen E, Tuisku J, Nuutinen S, Paavilainen T, Rokka J, Rinne J and Airas L. Evaluation of the effect of fingolimod on microglial activation using serial PET imaging in multiple sclerosis. JNM. 2017;58(10):1646-51​
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