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Traumatic brain injury research group
University of Turku Research Portal​​​

Tenovuo Olli_PIC.jpg

Olli Tenovuo, Docent, University of Turku and Head of Department, Turku University Hospital, Division of Clinical Neurosciences, Turku Brain Injury Center of Excellence

 
GOAL

Our main aim is to produce important new scientific data of the mechanisms of traumatic brain injury (TBI) and for the diagnostics of TBI, by using high-quality prospectively collected material. We aim at characterizing different injury types and combinations, improving their reliable detection, improving individual diagnostics and decision-making and at the same time clarifying the occurrence, detection and effect of different pathophysiological phenomena. In other words, we aim at raising the diagnostics of TBI to an improved level and clarifying the injury mechanisms in a way that facilitates the development of new treatment interventions. The main principles in our research activities are national and international networking, close collaboration between clinical and basic research, continuous connection between clinical care and scientific research, and creation of internationally unique facilities for clinical research of TBIs.

 
GROUP MEMBERS

Senior researchers

  • Juha Rinne, Professor
  • Janek Frantzén, Docent
  • Jussi Hirvonen, Docent
  • Päivi Hämäläinen, Docent
  • Timo Kurki, Docent
  • Jussi Posti, Docent, Co-Leader
  • Riikka Takala, Docent


Postdocs

  • Nina Brandstack
  • Juha Grönlund
  • Leena Himanen
  • Pekka Jokinen
  • Timo Roine

PhD students

  • Henna Ala-Seppälä
  • Iiro Heino
  • Iftakher Hossain
  • Emmi Kankaanpää
  • Ari Katila
  • Jussi Laalo
  • Henna-Riikka Maanpää
  • Shkar Maruf
  • Mehrbod Mohammadian
  • Marjaana Raukola-Lindbom
  • Mari Saarinen
  • Henri Salo
  • Samuel Söderqvist
  • Jussi Tallus
  • Jessina Uski
  • Minttu Vaittinen
  • Matias Yli-Olli
  • Anna Östberg

Research coordinator

  • Satu Timlin

KEY COLLABORATORS

  • University of Cambridge, UK
  • Imperial College London, UK
  • Oxford Brookes University, UK
  • University of Antwerp, Belgium
  • University of Pennsylvania, USA
  • Center for Neuroscience and Regenerative Medicine, Maryland (USA)
  • Hôpital Raymond Poincaré, France
  • University of Oslo, Norway
  • Karolinska Institutet, Sweden
  • University of Gothenburg, Sweden
  • University of Örebro, Sweden
  • University of Trnava, Slovakia
  • Erasmus Medical School, Netherlands
  • VTT Technical Research Centre of Finland
  • A.I.V. Institute (University of Eastern Finland)
  • Tampere University Hospital, Finland
  • Helsinki University, Finland
  • University of Turku, Dept. of Psychiatry
  • University of Turku, Dept. of Anatomy

LINK TO PAGES WITH MORE INFORMATION

 

https://www.researchgate.net/profile/Olli_Tenovuo

https://www.researchgate.net/profile/Jussi_Posti

​ 
SELECTED PUBLICATIONS
  1. Himanen L, Portin R, Isoniemi H, Helenius H, Kurki T, Tenovuo O. Longitudinal cognitive changes in traumatic brain injury: a 30 year follow-up study. Neurology 2006;66:187-92.
  2. Isoniemi H, Kurki T, Portin R, Kairisto V, Tenovuo O. Hippocampal volume, brain atrophy, and ApoE genotype after traumatic brain injury. Neurology 2006;67:756-760.
  3. Östberg A, Virta J, Rinne J, Oikonen V, Luoto P, Någren K, Arponen E, Tenovuo O. Cholinergic dysfunction after traumatic brain injury – preliminary findings from a PET study. Neurology 2011;76:1046-50.
  4. Brandstack N, Kurki T, Tenovuo O. Quantitative diffusion tensor tractography of long association tracts in patients with traumatic brain injury without findings in routine MRI. Radiology 2013;267:231-9.
  5. Orešič M, Posti JP, Kamstrup-Nielsen MH, Takala RSK, Lingsma HS, Mattila I, Jäntti S, Katila AJ, Carpenter KLH, Ala-Seppälä H, Kyllönen A, Maanpää H-R, Tallus J, Coles JP, Heino J, Frantzén J, Hutchinson PJ, Menon DK, Tenovuo O, Hyötyläinen T. Human serum metabolites associate with severity and patient outcomes in traumatic brain injury. EBioMedicine 2016;12:118-26.
  6. Maas AIR, Menon DK, Adelson PD et al. Traumatic brain injury – integrated approaches to improve prevention, clinical care, and research. Lancet Neurology 2017 Nov 6 [Epub ahead of print]
  7. Posti JP, Dickens Am, Orešič M, Hyötyläinen T, Tenovuo O. Metabolomics profiling as a diagnostic tool in severe traumatic brain injury. Frontiers in Neurology 2017 Aug 18;8:398.  
  8. Mohammadian M, Roine T, Hirvonen J, Kurki T, Ala-Seppälä H, Frantzén J, Katila A, Kyllönen A, Maanpää H-R, Posti J, Takala R, Tallus J, Tenovuo O. High angular resolution diffusion-weighted imaging in mild traumatic brain injury. Neuroimage: Clinical 2016;13:174-180.
  9. Posti JP, Katila AJ, Takala RSK, Runtti H, Newcombe V, Outtrim J, Frantzén J, Ala-Seppälä H, Coles JP, Hossain MI, Kyllönen A, Maanpää H-R, Tallus J, Hutchinson PJ, van Gils M, Menon DK, Tenovuo O; TBIcare investigators. The levels of GFAP and UCH-L1 during the first week after a traumatic brain injury: correlations with clinical and imaging findings. Neurosurgery 2016;79:456-64.
  10. Östberg A, Virta J, Rinne JO, Oikonen V, Luoto P, Någren K, Arponen E, Tenovuo O. Brain cholinergic function and response to rivastigmine in patients with chronic sequels of traumatic brain injury – a PET study. Journal of Head Trauma Rehabilitation 2017.

 
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