Johanna Schleutker profile picture
Johanna
Schleutker
Professor, Institute of Biomedicine
PhD, Professor of Medical Genetics

Contact

+358 29 450 2726
+358 50 443 7237
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Cancer genetics
hereditary cancer
genomics
human genetics

Biography

Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.

Teaching

Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.

Research

The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.

Publications

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Prostate cancer risk stratification improvement across multiple ancestries with new polygenic hazard score (2022)

Prostate Cancer and Prostatic Diseases
Huynh-Le MP, Karunamuni R, Fan CC, Asona L, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir KR, Lophatananon A, Schleutker J, Pashayan N, Batra J, Gronberg H, Neal DE, Nordestgaard BG, Tangen CM, MacInnis RJ, Wolk A, Albanes D, Haiman CA, Travis RC, Blot WJ, Stanford JL, Mucci LA, West CML, Nielsen SF, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sorensen KD, Cybulski C, Grindedal EM, Menegaux F, Park JY, Ingles SA, Maier C, Hamilton RJ, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Wiklund F, Penney KL, Huff CD, Teixeira MR, Multigner L, Leach RJ, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Ost P, Razack A, Newcomb LF, Fowke JH, Gamulin M, Abraham A, Claessens F, Castelao JE, Townsend PA, Crawford DC, Petrovics G, van Schaik RHN, Parent ME, Hu JJ, Zheng W, Mills IG, Andreassen OA, Dale AM, Seibert TM
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study (2022)

eLife
Morales Berstein Fernanda, McCartney Daniel L, Lu Ake T, Tsilidis Konstantintus K, Bouras Emmanouil, Haycock Philip, Burrows Kimberley, Phipps Amanda I, Buchanan Dnaiel D, Cheng Iona; PRACTICAL consortium, Martin Richardo M, Davey Smith George, Relton Caroline L, Horvath Steve, Marioni Riccardo E, Richardson Tom G, Richmond Rebecca C
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Rare Germline Variants in ATM Predispose to Prostate Cancer: A PRACTICAL Consortium Study (2021)

European Urology Oncology
Karlsson Questa, Brook Mark N, Dadaev Tokhir, Wakerell Sarah, Saunders Edward J, Muir Kenneth, Neal David E, Giles Graham G, MacInnis Robert J, Thibodeau Stephen N, McDonnell Shannon K, Cannon-Albright Lisa, Teixeira Manuel R, Paulo Paula, Cardoso Marta, Huff Chad, Li Donghui, Yao Yu, Scheet Paul, Permuth Jennifer B, Stanford Janet L, Dai James Y, Ostrander Elaine A, Cussenot Olivier, Cancel-Tassin Géraldine, Hoegel Josef, Herkommer Kathleen, Schleutker Johanna, Tammela Teuvo LJ, Rathinakannan Venkat, Sipeky Csilla, Wiklund Fredrik, Grönberg Henrik, Aly Markus, Isaacs William B, Dickinson Jo L, FitzGerald Liesel M, Chua Melvin LK, Nguyen-Dumont Tu, PRACTICAL Consortium, Schaid Daniel J, Southey Melissa C, Eeles Rosalind A, Kote-Jarai Zsofia
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (2021)

Nature Genetics
Conti David V., Darst Burcu F., Moss Lilit C., Saunders Edward J., Sheng Xin, Chou Alisha, Schumacher Fredrick R., Al Olama Ali Amin, Benlloch Sara, Dadaev Tokhir, Brook Mark N., Sahimi Ali, Hoffmann Thomas J., Takahashi Atushi, Matsuda Koichi, Momozawa Yukihide, Fujita Masashi, Muir Kenneth, Lophatananon Artitaya, Wan Peggy, Le Marchand Loic, Wilkens Lynne R., Stevens Victoria L., Gapstur Susan M., Carter Brian D., Schleutker Johanna, Tammela Teuvo L. J., Sipeky Csilla, Auvinen Anssi, Giles Graham G., Southey Melissa C., MacInnis Robert J., Cybulski Cezary, Wokołorczyk Dominika, Lubiński Jan, Neal David E., Donovan Jenny L., Hamdy Freddie C., Martin Richard M., Nordestgaard Børge G., Nielsen Sune F., Weischer Maren, Bojesen Stig E., Røder Martin Andreas, Iversen Peter, Batra Jyotsna, Chambers Suzanne, Moya Leire, Horvath Lisa, Clements Judith A., Tilley Wayne, Risbridger Gail P., Gronberg Henrik, Aly Markus, Szulkin Robert, Eklund Martin, Nordström Tobias, Pashayan Nora, Dunning Alison M., Ghoussaini Maya, Travis Ruth C., Key Tim J., Riboli Elio, Park Jong Y., Sellers Thomas A., Lin Hui-Yi, Albanes Demetrius, Weinstein Stephanie J., Mucci Lorelei A., Giovannucci Edward, Lindstrom Sara, Kraft Peter, Hunter David J., Penney Kathryn L., Turman Constance, Tangen Catherine M., Goodman Phyllis J., Ian M. Thompson Ian M. Jr., Hamilton Robert J., Fleshner Neil E., Finelli Antonio, Parent Marie-Élise, Stanford Janet L., Ostrander Elaine A., Geybels Milan S., Koutros Stella, Freeman Laura E. Beane, Stampfer Meir, Wolk Alicja, Håkansson Niclas, Andriole Gerald L., Hoover Robert N., Machiela Mitchell J., Sørensen Karina Dalsgaard, Borre Michael, Blot William J., Zheng Wei, Yeboah Edward D., Mensah James E., Lu Yong-Jie, Zhang Hong-Wei, Feng Ninghan, Mao Xueying, Wu Yudong, Zhao Shan-Chao, Sun Zan, Thibodeau Stephen N., McDonnell Shannon K., Schaid Daniel J., West Catharine M. L., Burnet Neil, Barnett Gill, Maier Christiane, Schnoeller Thomas, Luedeke Manuel, Kibel Adam S., Drake Bettina F., Cussenot Olivier, Cancel-Tassin Géraldine, Menegaux Florence, Truong Thérèse, Koudou Yves Akoli, John Esther M., Grindedal Eli Marie, Maehle Lovise, Khaw Kay-Tee, Ingles Sue A., Stern Mariana C., Vega Ana, Gómez-Caamaño Antonio, Fachal Laura, Rosenstein Barry S., Kerns Sarah L., Ostrer Harry, Teixeira Manuel R., Paulo Paula, Brandão Andreia, Watya Stephen, Lubwama Alexander, Bensen Jeannette T., Fontham Elizabeth T. H., Mohler James, Taylor Jack A., Kogevinas Manolis, Llorca Javier, Castaño-Vinyals Gemma, Cannon-Albright Lisa, Teerlink Craig C., Huff Chad D., Strom Sara S., Multigner Luc, Blanchet Pascal, Brureau Laurent, Kaneva Radka, Slavov Chavdar, Mitev Vanio, Leach Robin J., Weaver Brandi, Brenner Hermann, Cuk Katarina, Holleczek Bernd, Saum Kai-Uwe, Klein Eric A., Hsing Ann W., Kittles Rick A., Murphy Adam B., Logothetis Christopher J., Kim Jeri, Neuhausen Susan L., Steele Linda, Ding Yuan Chun, Isaacs William B., Nemesure Barbara, Hennis Anselm J. M., Carpten John, Pandha Hardev, Michael Agnieszka, De Ruyck Kim, De Meerleer Gert, Ost Piet, Xu Jianfeng, Razack Azad, Lim Jasmine, Teo Soo-Hwang, Newcomb Lisa F., Lin Daniel W., Fowke Jay H., Neslund-Dudas Christine, Rybicki Benjamin A., Gamulin Marija, Lessel Davor, Kulis Tomislav, Usmani Nawaid, Singhal Sandeep, Parliament Matthew, Claessens Frank, Joniau Steven, Van den Broeck Thomas, Gago-Dominguez Manuela, Castelao Jose Esteban, Martinez Maria Elena, Larkin Samantha, Townsend Paul A., Aukim-Hastie Claire, Bush William S., Aldrich Melinda C., Crawford Dana C., Srivastava Shiv, Cullen Jennifer C., Petrovics Gyorgy, Casey Graham, Roobol Monique J., Jenster Guido, van Schaik Ron H. N., Hu Jennifer J., Sanderson Maureen, Varma Rohit, McKean-Cowdin Roberta, Torres Mina, Mancuso Nicholas, Berndt Sonja I., Van Den Eeden Stephen K., Easton Douglas F., Chanock Stephen J., Cook Michael B., Wiklund Fredrik, Nakagawa Hidewaki, Witte John S., Eeles Rosalind A., Kote-Jarai Zsofia, Haiman Christopher A.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Two-stage Study of Familial Prostate Cancer by Whole-exome Sequencing and Custom Capture Identifies 10 Novel Genes Associated with the Risk of Prostate Cancer (2021)

European Urology
Daniel J.Schaid, Shannon K. McDonnell, Liesel M. FitzGerald, Lissa DeRycke, Zachary Fogarty, Graham G.Giles, Robert J. MacInnis, Melissa C.Southey, Tu Nguyen-Dumont, Geraldine Cancel-Tassin, Oliver Cussenot, Alice S.Whittemore, Weiva Sieh, Nilah Monnier Ioannidis, Chih-Lin Hsieh, Janet L. Stanford, Johanna Schleutker, Cheryl D. Cropp, John Carpten, Josef Hoegel, Rosalind Eeles, Zsofia Kote-Jarai, Michael J.Ackerman, Christopher J.Klein, Diptasri Mandal, Kathleen A.Cooney, Joan E.Bailey-Wilson, Brian Helfand, William J.Catalona, Fredrick Wiklund, Shaun Riska, Saurabh Bahetti,Melissa C.Larson, Lisa Cannon Albright, Craig Teerlink, Jianfeng Xu, William Isaacs, Elaine A.Ostrander, Stephen N.Thibodeau
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Polygenic hazard score is associated with prostate cancer in multi-ethnic populations (2021)

Nature Communications
Huynh-Le MP, Fan CC, Karunamuni R, Thompson WK, Martinez ME, Eeles RA, Kote-Jarai Z, Muir K, Schleutker J, Pashayan N, Batra J, Gronberg H, Neal DE, Donovan JL, Hamdy FC, Martin RM, Nielsen SF, Nordestgaard BG, Wiklund F, Tangen CM, Giles GG, Wolk A, Albanes D, Travis RC, Blot WJ, Zheng W, Sanderson M, Stanford JL, Mucci LA, West CML, Kibel AS, Cussenot O, Berndt SI, Koutros S, Sorensen KD, Cybulski C, Grindedal EM, Menegaux F, Khaw KT, Park JY, Ingles SA, Maier C, Hamilton RJ, Thibodeau SN, Rosenstein BS, Lu YJ, Watya S, Vega A, Kogevinas M, Penney KL, Huff C, Teixeira MR, Multigner L, Leach RJ, Cannon-Albright L, Brenner H, John EM, Kaneva R, Logothetis CJ, Neuhausen SL, De Ruyck K, Pandha H, Razack A, Newcomb LF, Fowke JH, Gamulin M, Usmani N, Claessens F, Gago-Dominguez M, Townsend PA, Bush WS, Roobol MJ, Parent ME, Hu JJ, Mills IG, Andreassen OA, Dale AM, Seibert TM; UKGPCS collaborators; APCB (Australian Prostate Cancer
BioResource); NC-LA PCaP Investigators; The IMPACT Study Steering Committee and Collaborators; Canary
PASS Investigators; The Profile Study Steering Committee; The PRACTICAL Consortium
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))