Jorma Toppari profile picture
Jorma
Toppari
InFLAMES Flagship
Professor, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

Publications J Toppari 2018 Nov.pdf
CV_Jorma_Toppari_ 2018_Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

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Umbilical cord blood DNA methylation in children who later develop type 1 diabetes (2022)

Diabetologia
Laajala Essi, Kalim Ubaid U, Grönroos Toni, Rasool Omid, Halla-aho Viivi, Konki Mikko, Kattelus Roosa, Mykkänen Juha, Nurmio Mirja, Vähä-Mäkilä Mari, Kallionpää Henna, Lietzen Niina, Ghimire Bishwa R, Laiho Asta, Hyöty Heikki, Elo Laura L, Ilonen Jorma, Knip Mikael, Lund Riikka J, Orešič Matej, Veijola Riitta, Lähdesmäki Harri, Toppari Jorma, Lahesmaa Riitta
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Telomere length is not a main factor for the development of islet autoimmunity and type 1 diabetes in the TEDDY study (2022)

Scientific Reports
Törn Carina, Liu Xiang, Onengut-Gumuscu Suna, Counts Kevin M, Moreno Jose Leonardo, Remedios Cassandra L, Chen Wei-Min, LeFaive Jonathon, Butterworth Martha D, Akolkar Beena, Krischer Jeffrey P, Lernmark Åke, Rewers Marian, She Jin-Xiong, Toppari Jorma, Ziegler Anette-Gabriele, Ratan Aakrosh, Smith Albert V, Hagopian William A, Rich Stephen S, Parikh Hemang M; The TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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