Matej Oresic profile picture
Matej
Oresic
Professor, Turku Bioscience Centre
InFLAMES Flagship
Ph.D.

Contact

+358 29 450 3798
+358 46 923 3395
Tykistökatu 6
20520
Turku

Areas of expertise

Systems biology
bioinformatics
metabolomics
lipidomics
biophysics
systems medicine
computational biology

Biography

Professor Matej Orešič holds a PhD in biophysics from Cornell University. He is Professor of Medical Sciences with Specialization in Systems Medicine at School of Medical Sciences (Örebro University, Sweden), Group Leader in Systems Medicine at the Turku Bioscience Centre (University of Turku, Finland), and Guest Professor at the Oil Crops Research Institute Chinese Academy of Agricultural Sciences (Wuhan, PR China). His main research areas are metabolomics applications in biomedical research and integrative bioinformatics. He is particularly interested in the identification of disease vulnerabilities associated with different metabolic phenotypes and the underlying mechanisms linking these vulnerabilities with the development of specific disorders or their co-morbidities, with specific focus on obesity and diabetes and their co-morbidities. Dr. Orešič has also initiated the popular MZmine open source project, leading to popular software for metabolomics data processing. Previosuly, Dr. Orešič was principal investigator at Steno Diabetes Center (Gentofte, Denmark), research professor at VTT Technical Research Centre of Finland (Espoo, Finland), head of computational biology and modeling at Beyond Genomics, Inc. (Waltham/MA) and bioinformatician at LION Bioscience Research in Cambridge/MA. In 2016, Dr. Oresic received the Lifetime Honorary Fellow award from the Metabolomics Society.

Research

Our main research area is systems medicine, particularly metabolomics applications in biomedical research and related integrative bioinformatics. Specifically, we am particularly interested in the identification of disease vulnerabilities associated with different metabolic phenotypes and the underlying mechanisms linking these vulnerabilities with the development of specific disorders or their co-morbidities. Such in depth understanding of the metabolic phenotypes in health and disease is crucial if one is to implement personalized medicine. Dr. Orešič initiated the popular MZmine open source project, leading to popular software for metabolomics data processing. Main ongoing projects: Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Metabolomic and Proteomic markers staging progression to type 1 diabetes in autoantibody positive children – PI Strategic Research Agreement, Juvenile Diabetes Research Foundation (9/2016-9/2018): Mother-infant interactions in relation to potential biomarkers of beta-cell autoimmunity and type 1 diabetes – PI Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (2012-2017) - PI Strategic Research Agreement, Juvenile Diabetes Research Foundation (Integrative multi-omic study of early progression to type 1 diabetes; 2014-2017) - PI pHealth Programme, multi-PI collaborative project, Academy of Finland (Personalised medicine to predict and prevent Type 1 Diabetes; 9/2015-8/2019) – Co-PI EU H2020 EPoS (Elucidating Pathways of Steatohepatitis) - Workpackage leader EU FP7 METSY (Integrated neuroimaging and metabolic platform for characterisation of early psychosis and prediction of patient outcomes) - Coordinator

Publications

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Technological readiness and implementation of genomic-driven precision medicine for complex diseases (2021)

Journal of Internal Medicine
Franks PW, Melen E, Friedman M, Sundstrom J, Kockum I, Klareskog L, Almqvist C, Bergen SE, Czene K, Hägg S, Hall P, Johnell K, Malarstig A, Catrina A, Hagström H, Benson M, Smith JG, Gomez MF, Orho-Melander M, Jacobsson B, Halfvarson J, Repsilber D, Oresic M, Jern C, Melin B, Ohlsson C, Fall T, Rönnblom L, Wadelius M, Nordmark G, Johansson Å, Rosenquist R, Sullivan PF
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking (2021)

European Heart Journal
Andersson Linda, Cinato Mathieu, Mardani Ismena, Miljanovic Azra, Arif Muhammad, Koh Ara, Lindbom Malin, Laudette Marion, Bollano Entela, Omerovic Elmir, Klevstig Martina, Henricsson Marcus, Fogelstrand Per, Swärd Karl, Ekstrand Matias, Levin Max, Wikström Johannes, Doran Stephen, Hyötyläinen Tuulia, Sinisalu Lisanna, Orešič Matej, Tivesten Åsa, Adiels Martin, Bergo Martin O, Proia Richard, Mardinoglu Adil, Jeppsson Anders, Borén Jan, Levin Malin C
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dysregulated lipid metabolism precedes onset of psychosis (2021)

Biological Psychiatry
Alex M Dickens, Partho Sen, Matthew J Kempton, Neus Barrantes-Vidal, Conrad Iyegbe, Merete Nordentoft, Thomas Pollak, Anita Riecher-Rössler, Stephan Ruhrmann, Gabriele Sachs, Rodrigo Bressan, Marie-Odile Krebs, G Paul Amminger, Lieuwe de Haan, Mark van der Gaag, Lucia Valmaggia, Tuulia Hyötyläinen, Matej Orešič, Philip McGuire
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species (2021)

Scientific Reports
Petersen Anders Ø, Julienne Hanna, Hyötyläinen Tuulia, Sen Partho, Fan Yong, Krogh Pedersen Helle, Jäntti Sirkku, Hansen Tue H., Nielsen Trine, Jørgensen Torben, Hansen Torben, Myers Pernille Neve, Nielsen H. Bjørn, Ehrlich S. Dusko, Orešič Matej, Pedersen Oluf
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))