Matti Poutanen profile picture
Matti
Poutanen
Professor, Institute of Biomedicine
InFLAMES Flagship
PhD

Contact

+358 29 450 2632
+358 50 366 0140
Kiinamyllynkatu 10
20520
Turku

Links

http://www.tcdm.fi/research/poutanen-matti/
ORCID

Areas of expertise

gentically modified mice
sex steroids
endometriosis
hormonal cancer

Biography

EDUCATIONAL TRAINING

1987, M.Sc., Department of Biochemistry, University of Oulu, Finland

1993, Ph.D., Department of Clinical Chemistry, University of Oulu, Finland         

1997, Title of Docent (Adjunct professor); Biochemical Endocrinology, University of Oulu, Finland   


CURRENT POSITIONS

Professor, Department of Physiology, University of Turku, and Director of Turku Center for Disease Modeling, University of Turku, Finland

Senior Scientist lecturer, Institute of Medicine, The Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden

MAJOR GRANTS:
Academy of Finland, The Finnish Cancer Organisations, Sigrid Juselius Foundation, Novo Foundation, Vetenskaps Rådet, Business Finland and Industry

SUPERVISION OF STUDENTS: 30 PhD students supervised, 6 in training.

SCIENTIFIC AND SOCIETAL IMPACT OFD THE WORK

Research is mainly focused on sex steroid synthesis and action, with total number of citation 6270 (Web of Science, April 2018); number of citations in 2017: ~400; average citations per article: 26.8; h-index: 46; 182 original peer-reviewed publications; 5 publications in high-impact journals (I.F. ≥ 10): J. Clin. Invest. 2x (I.F. 13), Cell Metab.(I.F. 17), Nat. Med. (I.F. 28), Gut (I.F. 14)

 Co-founder, Forendo Pharma ltd (www.forendo.com) focusing on hormonal therapies for endometriosis and male hypogonadism. The company has closed its investment rounds with the leading Nordic start-up investors Karolinska Development AB, Novo Seeds and Finnvera. 

Teaching

Teaching experience in, endocrinology, developmental biology, hormonal cancer, GM mice and animal models and in vivo imaging

Research

Our research group has been internationally in a key position in providing evidence for the concept where the ligand concentration available for steroid hormone receptor binding is markedly regulated by the target tissue metabolism, termed intracrine steroid hormone action. The concept has proven to be essential for the growth and progression of both prostate and breast cancer. We, furthermore, have shown this concept to be valid also in premenopausal women, eg. in the endometriosis, and other medically relevant implications are expected to rise in the near future.

Publications

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Deep Learning-Based Image Analysis of Liver Steatosis in Mouse Models (2023)

American Journal of Pathology
Mairinoja Laura, Heikelä Hanna, Blom Sami, Kumar Darshan, Knuuttila Anna, Boyd Sonja, Sjöblom Nelli, Birkman Eva-Maria, Rinne Petteri, Ruusuvuori Pekka, Strauss Leena, Poutanen Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Dicer ablation in Kiss1 neurons impairs puberty and fertility preferentially in female mice (2022)

Nature Communications
Roa Juan, Ruiz-Cruz Miguel, Ruiz-Pino Francisco, Onieva Rocio, Vazquez Maria J., Sanchez-Tapia Maria J., Ruiz-Rodriguez Jose M., Sobrino Veronica, Barroso Alexia, Heras Violeta, Velasco Inmaculada, Perdices-Lopez Cecilia, Ohlsson Claes, Avendano Maria Soledad, Prevot Vincent, Poutanen Matti, Pinilla Leonor, Gaytan Francisco, Tena-Sempere Manuel
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Overexpression of Human Estrogen Biosynthetic Enzyme Hydroxysteroid (17beta) Dehydrogenase Type 1 Induces Adenomyosis-like Phenotype in Transgenic Mice (2022)

International Journal of Molecular Sciences
Heinosalo Taija, Rytkönen Kalle T., Saarinen Niina, Järvensivu Päivi, Damdimopoulou Pauliina, Strauss Leena, Orasniemi Satu, Horshauge Petricia, Gabriel Michael, Koskimies Pasi, Ohlsson Claes, Kronqvist Pauliina, Poutanen Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

High intratumoral dihydrotestosterone is associated with antiandrogen resistance in VCaP prostate cancer xenografts in castrated mice (2022)

iScience
Huhtaniemi Riikka, Sipilä Petra, Junnila Arttu, Oksala Riikka, Knuuttila Matias, Mehmood Arfa, Aho Eija, Laajala Teemu D., Aittokallio Tero, Laiho Asta, Elo Laura, Ohlsson Claes, Thulin Malin H., Kallio Pekka, Mäkelä Sari, Mustonen Mika V.J., Poutanen Matti
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Congenital Hypothyroidism and Hyperthyroidism Alters Adrenal Gene Expression, Development, and Function (2022)

Thyroid
Patyra Konrad, Löf Christoffer, Jaeschke Holger, Undeutsch Hendrik, Zheng Huifei Sophia, Tyystjärvi Sofia, Puławska Kamila, Doroszko Milena, Chruściel Marcin, Loo Britt-Marie, Kurkijärvi Riikka, Zhang Fu-Ping, Huang Chen-Che Jeff, Ohlsson Claes, Kero Andreina, Poutanen Matti, Toppari Jorma, Paschke Ralf, Rahman Nafis, Huhtaniemi Ilpo, Jääskeläinen Jarmo, Kero Jukka
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
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