Olli Tenovuo profile picture
Olli
Tenovuo
Professor, Clinical Neurosciences
MD, PhD, Prof. of Neurotraumatology
Pathophysiology, diagnostics, treatment, and prognosis of traumatic brain injury

Contact

Areas of expertise

traumatic brain injury
rehabilitation
biomarkers
imaging

Biography

I have a long and profound experience in the field of traumatic brain injuries (TBIs), both clinically and scientifically. Patients with TBI of different severities have been my main clinical interest since early 1990’s, and during the years I have treated about 6 000 patients with TBI. Since 1996 I have led a multidisciplinary research group on TBIs, which has expanded steadily. Currently our group includes > 40 researchers, 21 of which are PhD students and 7 are post docs. They represent widely different disciplines, such as neurosurgery, neurology, neuroanaesthesiology, neuroradiology, neuropsychology, clinical neurophysiology, psychiatry etc. I have conducted also large international research projects and am currently in a leading position in several trials. I have also experience on RCTs on the field. My group has a wide collaborative network both nationally and internationally, both in experimental and clinical research. Currently we have active research collaboration with ten national and 22 international (from 13 countries) research groups.

Teaching

Teaching about TBI has been a major part of my work for almost 20 years, both for medical students at the Turku University as well as nationally and internationally. Annually I have about 160 hrs of teaching for medical students.

Research

The research of our TBI has included topics from various disciplines, from psychiatry and neuropsychology to epidemiology, neurosurgery, and biochemistry. During the recent years we have mainly focused in three areas: 1) blood-based brain injury biomarkers, 2) novel brain imaging methodologies, and 3) multifaceted approach to diagnostic and prognostic modeling of TBI. We aim at solving clinical problems and conducting research which is easily transferred to clinical practice. We also collaborate with basic science in order to reveal brain injury mechanisms, since these help in understanding clinical phenomena and in developing new interventions. International collaboration and co-work are an essential part of our research policy.

Publications

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Serum metabolome associated with severity of acute traumatic brain injury (2022)

Nature Communications
Thomas Ilias, Dickens Alex M, Posti Jussi P, Czeiter Endre, Duberg Daniel, Sinioja Tim, Kråkström Matilda, Helmrich Isabel RA Retel, Wang Kevin KW, Maas Andrew IR, Steyerberg Ewout W, Menon David K, Tenovuo Olli, Hyötyläinen Tuulia, Büki András, Orešič Matej; Group author: CENTER-TBI Participants and Investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Primary versus early secondary referral to a specialized neurotrauma center in patients with moderate/severe traumatic brain injury: a CENTER TBI study (2021)

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Sewalt Charlie Aletta, Gravesteijn Benjamin Yaël, Menon David, Lingsma Hester Floor, Maas Andrew IR, Stocchetti Nino, Venema Esmee, Lecky Fiona E; CENTER-TBI Participants and Investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Patient-specific ICP epidemiologic thresholds in adult traumatic brain injury: A CENTER-TBI validation study (2021)

Journal of Neurosurgical Anesthesiology
Zeiler Frederick A, Ercole Ari, Cabeleira Manuel, Beqiri Erta, Zoerle Tommaso, Carbonara Marco, Stocchetti Nino, Menon David K, Lazaridis Christos, Smielewski Peter, Czosnyka Marek; CENTER-TBI High Resolution ICU Sub-Study Participants and Investigators.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Differences between Men and Women in Treatment and Outcome after Traumatic Brain Injury (2021)

Journal of Neurotrauma
Mikolić Ana, van Klaveren David, Oude Groeniger Joost, Wiegers Eveline JA, Lingsma Hester F, Zeldovich Marina, von Steinbüchel Nicole, Maas Andrew IR, Roeters van Lennep Jeanine E, Polinder Suzanne; CENTER-TBI Participants and Investigators
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))