B lymphocytes are key cells in mounting the adaptive immune response by differentiating into antibody secreting plasma cells. Our group is interested in the molecular mechanisms of B lymphocyte activation, with emphasis on receptor activation and its immediate cell biological responses, culminating at the reorganization of the actin cytoskeleton, plasma membrane and intracellular vesicle traffic. In our research, we take advantage of both in vivo models and various advanced imaging techniques, including super-resolution microscopy, as well as modern proteomic approaches such as APEX2 proximity biotinylation.

More information about our projects, including our publications, can be found at: http://mattilalab.utu.fi.