Santosh Lamichhane profile picture
Santosh
Lamichhane
Docent, Department of Life Technologies
PostDoctoral Researcher, Turku Bioscience Centre
PhD (Metabolomics)

Areas of expertise

Lipidomics/Metabolomics
Systems medicine
Gut metabolome
Multivariate data analysis

Biography

Santosh Lamichhane is Docent in Metabolomics at  Department of Life Technologies, University of Turku. He works as a Post-doctoral researcher, at Turku Bioscience Center. Lamichhane's PhD project involved development of metabolomics platform to elucidate the effects of Ploydextrose (synthetic fiber) on activity of the gut microbiota both in vivo and in vitro in the colon. During his PhD Lamichhane visited Bio-system data analysis Group at University of Amsterdam to enhance his skills in Multivariate Data analysis. He completed his Master's in Molecular medicine from Norwegian University of Science and Technology, Trondheim, Norway. During his masters he had been working with cancer cell metabolism, in particular being focused on Breast tumor tissues.

Teaching

Metabolomics lecture in Systems biology (SYS21012), Modern biotechnologies and bioinformatics course (BIOT1524), Bioanalytical Techniques (CHEMI6429) at University of Turku.


Research

Lamichhane's research interest lies in the interface of human health, diet and gut microbial activity. He wants to connect these dots (health, diet, microbes) by profiling small molecules (termed as metabolites), which circulates in our body. To be very specific Lamichhanes core interest are reflected by following keywords:

- Metabolomics-Metabolites-Small molecules
- Human Nutrition and health
- Pre and Probiotics / Gut Microbiome
- Human intervention study

Relating to Lamichhane's experience, he has spent approximately a decade profiling small molecules in relation to human heath and (or) gut metabolome. He is open to collaborations relating to gut, health, metabolites and microbiome

Publications

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Systems biology approaches to study lipidomes in health and disease (2021)

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids
Marina Amaral Alves, Santosh Lamichhane, Alex Dickens, Aidan McGlinchey, Henrique C Ribeiro, Partho Sen, Fang Wei, Tuulia Hyötyläinen, Matej Orešič
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Metabolic alterations in immune cells associate with progression to type 1 diabetes (2020)

Diabetologia
Partho Sen, Alex M. Dickens, María Asunción López-Bascón, Tuomas Lindeman, Esko Kemppainen, Santosh Lamichhane, Tuukka Rönkkö, Jorma Ilonen, Jorma Toppari, Riitta Veijola, Heikki Hyöty, Tuulia Hyötyläinen, Mikael Knip, Matej Orešič
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes (2020)

Environment International
Aidan McGlinchey, Tim Sinioja, Santosh Lamichhane, Partho Sen, Johanna Bodin, Heli Siljander, Alex M Dickens, Dawei Geng, Cecilia Carlsson, Daniel Duberg, Jorma Ilonen, Suvi M Virtanen, Hubert Dirven, Hanne F Bentsen, Karin Zimmer, Unni C Nygaard, Matej Oresic, Mikael Knip, Tuulia Hyotylainen
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes (2019)

Biomolecules
Lamichhane Santosh, Ahonen Linda, Dyrlund Thomas Spartholt, Dickens Alex M., Siljander Heli, Hyöty Heikki, Ilonen Jorma, Toppari Jorma, Veijola Riitta, Hyötyläinen Tuulia, Knip Mikael, Oresic Matej
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))