Teijo
Saari
Professor, Anaesthesiology, Intensive Care
MD, PhD. Head of Department
Precise and new therapeutic possibilities to acute pain medicine.
Contact
Areas of expertise
Pain medicine
Analgesia
Modelling & Simulation
Pharmacometrics
Clinical Pharmacology
Drug-Drug-Interactions
Biography
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral
fellow in University of Erlangen-Nuremberg, Germany in pharmacometric
research project: ’PEP’ – Personalized Effect-Controlled
Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Teaching
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Research
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Publications
Voriconazole greatly increases the exposure to oral buprenorphine (2018)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Deksmedetomidiinin intranasaalinen annostelu (2018)
Finnanest
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Semimechanistic Population Pharmacokinetic Model to Predict the Drug–Drug Interaction Between S-ketamine and Ticlopidine in Healthy Human Volunteers (2018)
CPT: Pharmacometrics and Systems Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Sequential Organ Failure Assessment (SOFA) to Predict Pressure Ulcer Risk in Intensive Care Patients: A Retrospective Cohort Study (2018)
Ostomy Wound Management
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Mitä on anestesialääkäri? (2017)
Finnanest
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))
Patient-controlled Analgesia with Target-controlled Infusion of Hydromorphone in Postoperative Pain Therapy (2016)
Anesthesiology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Voriconazole more likely than posaconazole increases plasma exposure to sublingual buprenorphine causing a risk of a clinically important interaction (2016)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Rifampicin decreases exposure to sublingual buprenorphine in healthy subjects (2016)
Pharmacology Research and Perspectives
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Ketamine: A Review of Clinical Pharmacokinetics and Pharmacodynamics in Anesthesia and Pain Therapy (2016)
Clinical Pharmacokinetics
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
Olisiko hydromorfonista oksikodonin haastajaksi? (2016)
Finnanest
(Artikkeli ammattilehdessä tai kirjoitus ammatillisessa blogissa (D1))