Teijo
Saari
Professor, Anaesthesiology, Intensive Care
MD, PhD. Head of Department
Precise and new therapeutic possibilities to acute pain medicine.
Contact
Areas of expertise
Pain medicine
Analgesia
Modelling & Simulation
Pharmacometrics
Clinical Pharmacology
Drug-Drug-Interactions
Biography
Professor Teijo Saari (MD, PhD, University of Turku) is a specialist in anesthesiology and intensive care and cardiac anesthesia at the Turku University Hospital, Turku, Finland. Since 2004, he has been conducting research on clinical pharmacology examining the pain therapeutics and anesthetics and developing pharmacometric models for precise drug dosing. His PhD work evaluated drug-drug interactions between antimycotes and drugs used in anesthesiology and pain medicine (University of Turku, April 2005). In 2011-2013 he worked as post doctoral
fellow in University of Erlangen-Nuremberg, Germany in pharmacometric
research project: ’PEP’ – Personalized Effect-Controlled
Pharmacotherapy. Since 2013, he has lead his research group focusing on acute pain medicine. In January 2017, he was appointed to Tenure Track as Associate Professor and in June 2021 as Full Professor and Chairman of Anesthesiology and Intensive Care at the University of Turku.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
His career publications total is 57 (h-index 20) with published highlights including high-ranked papers in Anesthesiology, British Journal of Anesthesiology and Clinical Pharmacokinetics.
Teaching
Teaching responsibilities: 1) Anesthesiology and Intensive care for medical students, 2) Graduate studies for MDs
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Special interest areas: Acute pain medicine, cardiac anesthesia, clinical pharmacology
Research
Professor Saari's principal research focus has been to provide novel information on therapeutics used in acute pain medicine. Beginning from 2013 he has led a research group with special interest on model-informed precision dosing and development of new dosing modalities for pain therapeutics. Important aspect of his research has been a pursuit to reduce opioid use with adjuvants added to the opioid therapy in the postoperative setting. His work has demonstrated that pharmacometric models can improve the precision of drug dosing during postoperative phase. Furthermore, his studies have established covariate effects explaining between-patient variability. His future aim is to discover biomarkers that can predict chronic pain development.
Publications
Azole antimycotics and drug interactions in the perioperative period (2010)
Current Opinion in Anaesthesiology
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))
Effects of itraconazole on the pharmacokinetics and pharmacodynamics of intravenously and orally administered oxycodone (2010)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Grapefruit Juice Enhances the Exposure to Oral Oxycodone (2010)
Basic and Clinical Pharmacology and Toxicology Supplement
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Voriconazole drastically increases exposure to oral oxycodone (2009)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Rifampin Greatly Reduces the Plasma Concentrations of Intravenous and Oral Oxycodone (2009)
Anesthesiology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Effect of voriconazole and fluconazole on the pharmacokinetics of intravenous fentanyl (2008)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of zolpidem in healthy subjects (2007)
British Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Voriconazole and fluconazole increase the exposure to oral diazepam (2007)
European Journal of Clinical Pharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life (2006)
Clinical Pharmacology and Therapeutics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Effect of voriconazole on the pharmacokinetics and pharmacodynamics of intravenous and oral midazolam (2006)
Clinical Pharmacology and Therapeutics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))