Veijo Hukkanen profile picture
Veijo
Hukkanen
Clinical Lecturer, Institute of Biomedicine
Adjunct Professor, Faculty of Medicine
MDPhD
Novel RNA-mediated antiviral therapies; Gene therapy and herpesvirus vectors

Contact

+358 29 450 4552
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Virology
Herpesviruses
Gene Therapy
Oncolytic viruses
Antivirals
RNA interference

Biography

Chairperson of the Institute of Microbiology and Pathology (Kliinis-teoreettinen laitos) 2001-2003

Convener and Co-chair of the International Herpesvirus conference IHW2005, Turku, 2005

Professor at the Department of Medical Microbiology, University of Oulu (virology) 2005-2009

Professor at the Department of Virology, University of Turku, 2010-2013

Herpesvirology research 1983-current

Thesis work on neuroimmunology and neurovirology 1978-1982

Teaching

I have 4 decades of experience and interest in activating teaching of Virology, to students of medicine and biomedicine. My teaching is based on scientific research.

I have completed the first ever organized training course in University Pedagogics in the University of Turku, and the first organized training course in Medical Pedagogics in the University of Turku.

Research

Herpes simplex virus (HSV) is a common pathogen of humans, causing a spectrum of infections ranging from cold sores and genital herpes to the serious neonatal herpes infections and encephalitis. However, HSV is also one of the most important oncolytic viruses (destroying cancer cells) and gene therapy vectors. A characteristic feature of HSV is the latent infection in the nervous system, mainly in sensory ganglia. The latent HSV infection is permanent, although recurrencies can be treated with antiviral chemotherapy. Our project develops means for prevention and treatment of virus infection and viral latency. We have established a successful RNA interference approach, using enzymatically produced antiviral siRNA swarms, for control of HSV infection, as a joint project with the premier RNA research laboratory in Finland. 

HSV is a promising backbone for gene therapy vectors, due to its neurotropism, its immune evasion abilities, drug sensitivity and numerous other beneficial properties. An oncolytic HSV has gained approval by the FDA and the European Medicines Agency.  Our team has long-term experience in developing HSV vectors. We construct novel HSV recombinant viruses and study the use of these attenuated viruses in gene therapy of central nervous system diseases. We also develop oncolytic HSV for treatment of cancer. Our research has produced new HSV vectors, from which therapeutic cytokines and trophic factors are expressed.  We improve delivery and targeting methods for HSV gene therapy. 

We elucidate the genetic diversity among HSV strains from natural clinical isolates. We apply NGS sequencing methods suitable for analysis of large DNA viruses, in collaboration with a pioneer laboratory of the field. These studies benefit antiviral development, pathogenesis studies, and virus vector development. We also improve molecular diagnostic methods for the herpes viruses in clinical diseases, having many decades of experience in HSV nucleic acid detection. We collaborate with significant domestic and international research groups. Our project has yielded over 10 doctoral dissertations, in addition to over 20 MSc theses and numerous special projects in fields of biomedicine and other biosciences.

Publications

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Virusinfektioiden patogeneesi (2020)

Veijo Hukkanen, Kalle Saksela, Heikki Hyöty, Ilkka Julkunen
(D2 Artikkeli ammatillisessa kokoomateoksessa)

Comparison of Clinically Relevant Oncolytic Virus Platforms for Enhancing T Cell Therapy of Solid Tumors (2020)

Molecular Therapy - Oncolytics
Victor Cervera-Carrascon, Dafne C.A. Quixabeira, Riikka Havunen, Joao M. Santos, Emma Kutvonen, James H.A. Clubb, Mikko Siurala, Camilla Heiniö, Sadia Zafar, Teija Koivula, Dave Lumen, Marjo Vaha, Arturo Garcia-Horsman, Anu J.Airaksinen, Suvi Sorsa, Marjukka Anttila, Veijo Hukkanen, Anna Kanerva, Akseli Hemminki
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)

Herpesvirusten ryhmä (2020)

Veijo Hukkanen, Mikko Seppänen, Tea Nieminen, Irmeli Lautenschlager, Veli-Jukka Anttila, Pia Kivelä, Päivi Ojala
(D2 Artikkeli ammatillisessa kokoomateoksessa)

Novel activities of safe-in-human broad-spectrum antiviral agents (2018)

Antiviral Research
Aleksandr Ianevski, Eva Zusinaite, Suvi Kuivanen, Mårten Strand, Hilde Lysvand, Mona Teppor, Laura Kakkola, Henrik Paavilainen, Mira Laajala, Hannimari Kallio-Kokko, Miia Valkonen, Anu Kantele, Kaidi Telling, Irja Lutsar, Pille Letjuka, Natalja Metelitsa, Valentyn Oksenych, Magnar Bjørås, Svein Arne Nordbø, Uga Dumpis, Astra Vitkauskiene, Christina Öhrmalm, Kåre Bondeson, Anders Bergqvist, Tero Aittokallio, Rebecca J. Cox, Magnus Evander, Veijo Hukkanen, Varpu Marjomaki, Ilkka Julkunen, Olli Vapalahti, Tanel Tenson, Andres Merits, Denis Kainov
(A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä)