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PET imaging of neuropathological changes in animal models of Alzheimer's disease

​Description of Research

We aim to use positron emission tomography (PET) to investigate the effects of endocannabinoid modulation, brain energy metabolism, neuroinflammation, norepinephrine function, and beta-amyloid plaque and tau formation, as well as their connections to each other in animal models of Alzheimer's disease (AD). Improving our understanding of AD pathophysiology requires specific and sensitive non-invasive methods for the functional characterisation of brain function in vivo. The exploration of these connections and their respective
 oles in neuronal loss and AD neurodegeneration has important implications for both clinical practice and for future therapeutic interventions.

Members of the research group:

Anniina Snellman, MSc, doctoral candidate
Jatta Takkinen, MSc, doctoral candidate
Susanne Vainio, MSc, doctoral candidate
Tomas Keller, MSc, doctoral candidate
Anna Krzyczmonik, MSc, doctoral candidate
Rea Pihlaja, PhD, senior reseacher
Johanna Rokka, PhD, senior researcher
Sarita Forsback, PhD, senior researcher
Anna Kirjavainen, PhD, senior researcher
Olof Solin, PhD, Prof. of radiochemistry
Juha Rinne, PhD, MD, Prof. of neurotransmission
Elisa Riuttala, laboratory technician
Marko Vehmanen, laboratory technician

Selected publications:

Takkinen JS, López-Picón FR, Al Majidi R, Eskola O, Krzyczmonik A, Keller T, Löyttyniemi E, Solin O, Rinne JO and Haaparanta-Solin M. Brain energy metabolism and neuroinflammation in ageing APP/PS1-21 mice using longitudinal 18F-FDG and 18F-DPA-714 PET imaging. J Cereb Blood Flow Metab (2016). DOI:10.1177/0271678X16677990.

Rokka J, Snellman A, Kaasalainen M, Salonen J, Zona C, La Ferla B, Nicotra F, Re F, Masserini M, Forsback S, Lopez-Picon F, Rinne JO, Haaparanta-Solin M, Solin O. 18F-labeling syntheses and preclinical evaluation of functionalized nanoliposomes for Alzheimer´s disease. Eur J Pharm Sci, 35 (2015) 766–772.

Snellman A, Rokka J, Lopez-Picon FR, Eskola O, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M. In vivo PET imaging of beta-amyloid deposition in mouse models of Alzheimer's disease with a high specific activity PET imaging agent [18F]flutemetamol. EJNMMI Research 4 (2014) 37.

Snellman A, López-Picón FR, Rokka J, Salmona M, Forloni G, Scheinin M, Solin O, Rinne JO, Haaparanta- Solin M. Longitudinal amyloid imaging in mouse brain with [11C]PIB — comparison of APP23, Tg2576 and APPswe-PS1dE9 mouse models of Alzheimer’s disease. J Nucl Med 54 (2013) 1434–1441.

Snellman A, Rokka J, Lopez-Picon F, Eskola O, Wilson I, Farrar G, Scheinin M, Solin O, Rinne JO, Haaparanta-Solin M. Pharmacokinetics of [18F]flutemetamol in wild-type rodents and its binding to beta amyloid deposits in a mouse model of Alzheimer’s disease. Eur J Nucl Med Mol Imaging. 39 (2012) 1784–1795.

 
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 Docent Merja Haaparanta-Solin

 
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