Suomeksi
 
 
Myeloid cells in regulation of chronic inflammation, autoimmunity and tumor microenvironment

​Description of Research

In this research project the function of myeloid cells in regulation of immune responses is evaluated. This includes chronic inflammations and autoimmunity as well as the role of tumor associated mac-rophages (TAMs) in maintaining an immunosuppressive status in the tumor microenvironment and promotion of cancer cell migration and invasion. Special emphasis is put on the (exosomal) miRNA communication between different cell populations locally and distally. Further, novel treatment mo-dalities based either on hormone receptor signaling or the pleiotropic effects of bisphosphonate (induced) metabolites are being sought to modulate the function of the myeloid cell population more feasible for the patient.

Members of the research group

Lauri Polari, Ph.D.
Ameya Bendre, M. Tech
Sofia Sousa, M.Sc.
Hristo Zlatev, MD
Mervi Laanti, B.Sc.

Selected Publications

Sofia Sousa, Régis Brion, Minnamaija Lintunen, Pauliina Kronqvist, Jouko Sandholm, Jukka Mönkkönen, Heikki Joensuu, Dominique Heymann, Jorma Määttä. (2015) Human breast cancer cells educate macrophages toward the M2 activation status. Breast Cancer Research, 17:101 doi: 10.1186/s13058-015-0621-0

Sofia Sousa, Seppo Auriola, Jukka Mönkkönen, Jorma Määttä. (2015) N-BPs skew murine macrophages cultured with soluble factors from breast cancer cells toward M1 phenotype. BMC Cancer, 15:4.

Satu Arkko, Hristo P. Zlatev, Hannu Mönkkönen, Johanna Räikkönen, Ismahene Bendzaïd, Philippe Clézardin, Jukka Mönkkönen and Jorma A. Määttä. (2015) Upregulation of the mevalonate pathway by cholesterol depletion abolishes tolerance to N-bisphosphonate induced V9V2 T cell cytotoxicity in PC-3 prostate cancer cells. Cancer Letters, 357, 279-85 doi: 10.1016/j.canlet.2014.11.030.

Jorma A. Määttä, Kalman G. Büki, Guoliang Gu, Maria H. Alanne, Jukka Vääräniemi, Heidi Liljenbäck, Matti Poutanen, Pirkko Härkönen and Kalervo Väänänen (2013) Inactivation of Estrogen Receptor Alpha in Bone Forming Cells Induces Bone Loss in Female Mice. Faseb Journal, 27, 478-488.

Jorma A. Määttä, Vappu Nieminen-Pihala, Kalman G. Büki, Teresa D. Elo, Tiina Silvola, Matti Poutanen, Pirkko Härkönen and Kalervo Väänänen. (2013) Inactivation of the Androgen Receptor in Bone Forming Cells Leads to Trabecular Bone Loss in Adult Female Mice. BoneKEy Reports 2, Article number: 440, doi:10.1038/bonekey.2013.174

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