Suomeksi
 
 
Anesthesia Mechanisms

harry scheinin_PIC1.jpg
Harry Scheinin
, Adjunct Professor, Turku PET Centre, University of Turku
 
GOAL 

We try to explore the neural correlates of human consciousness using, e.g., modern imaging methods. We aim to separate consciousness from responsiveness, connectedness from disconnection and to compare unconsciousness of physiological sleep with that induced by anesthetic agents. Finding new tools for the distinction of consciousness, connectedness and responsiveness would be groundbreaking and could represent a major leap forward in understanding human consciousness. The results could also help in developing new EEG-based methods to objectively measure consciousness and the depth of general anesthesia. 

GROUP MEMBERS

Principal Investigator

Senior researchers

  • Kaike Kaisti
  • Kimmo Kaskinoro
  • Ruut Laitio
  • Timo Laitio
  • Jaakko Långsjö
  • Anu Maksimow
Graduate students
  • Oskari Kantonen
  • Aleksi Nummela
  • Lauri Laaksonen
  • Linda Radek
  • Annalotta Scheinin
 Undergraduate students
  • Jarno Korhonen
  • Aleksi Palola​
 COLLABORATIONS

  •  Michael Alkire, University of California, Irvine, USA
  • Anthony Hudetz, University of Michigan, USA
  • George Mashour, University of Michigan, USA
  • Lauri Nummenmaa, University of Turku and Aalto University
  • Antti Revonsuo, University of Turku, Turku Finland and University of Skövde, Skövde, Sweden
  • Mika Scheinin, University of Turku, Turku, Finland

 SELECTED PUBLICATIONS

  1. Laaksonen L, Kallioinen M, Långsjö J, Laitio T, Scheinin A,  Scheinin J, Kaisti K, Maksimow A,  Kallionpää RE, Rajala V, Johansson J, Kantonen O, Nyman M, Sirén S, Valli K, Revonsuo A, Solin O, Vahlberg T,  Alkire M, Scheinin H. Comparative effects of dexmedetomidine, propofol, sevoflurane and S-ketamine on regional cerebral glucose metabolism in humans: A positron emission tomography study. Brit J Anaesth, in press.
  2. Maksimow A, Silfverhuth M, Långsjö J, Kaskinoro K, Georgiadis S, Jääskeläinen S, Scheinin H. Directional connectivity between frontal and posterior brain regions is altered with increasing concentrations of propofol. PLoS ONE 2014 Nov 24;9(11):e113616. doi: 10.1371/journal.pone.0113616. eCollection 2014.
  3. Långsjö JW, Alkire MT, Kaskinoro K, Hayama H, Maksimow A, Kaisti KK, Aalto S, Aantaa R, Jääskeläinen SK, Revonsuo A, Scheinin H. Returning from oblivion: imaging the neural core of consciousness; J Neurosci 2012;32:4935-4943.
  4. Kaisti KK, Långsjö JW, Aalto S, Oikonen V, Sipilä H, Teräs M, Hinkka S, Metsähonkala L, Scheinin H. Effects of sevoflurane, propofol, and adjunct nitrous oxide on regional cerebral blood flow, oxygen consumption, and blood volume in humans. Anesthesiology 2003;99:603-613.
  5. Kaisti KK, Metsähonkala L, Teräs M, Oikonen V, Aalto S, Jääskelainen S, Hinkka S, Scheinin H. Effects of surgical levels of propofol and sevoflurane anesthesia on cerebral blood flow in healthy subjects studied with positron emission tomography. Anesthesiology 2002;96:1358-1370.
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