Frontiers of Science: Dr. Gertraud Orend


31.1.2019 klo 12.00 - 13.00
Dr. Gertraud Orend, INSERM, Strasbourg, France
Roles of the extracellular matrix molecule tenascin-C in cancer

Host: Johanna Ivaska (

Dr. Gertraud Orend leads the tumour microenvironment group in the INSERM institute in Strasbourg, France. Her group focuses on the multifaceted roles of the extracellular matrix molecule tenascin-C in cancer, where its abundance correlates with metastasis and poor patient survival. They have developed the first stochastic tumour model with abundant and no tenascin-C expression, and have demonstrated that tenascin-C promotes lung metastasis by supporting multiple steps including cell survival and migration, the angiogenic switch and non-productive angiogenesis through the Wnt signalling pathway. In a murine xenograft model of advanced human osteosarcoma, they have found that tenascin-C and its receptor integrin a9ß1 are essential for the formation of lung metastases through the inhibition of YAP. The Orend group also investigate how breast cancer and other tumours highjack our immune system for their own advantage and aim to find ways of restoring the immune system’s anti-cancer activity.


Jokilehto, Terhi