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Genetic Predisposition to Cancer

schleutker.jpg


Principal investigator

Johanna Schleutker
Professor

 

  

Contact information
Address
Department of Medical Biochemistry and Genetics
Institute of Biomedicine
Kiinamyllynkatu 10
FI-20014 University of Turku
Finland

Phone : +358 2 333 7453
Fax : +358 2 230 1280
Email :  johanna.schleutker (at) utu.fi

 

Description of the research
Major project is on prostate cancer genetics. Our studies are addressing the need to identify the causative genetic events leading to prostate cancer. We are doing genomic research, which is based on our nation-wide genetic epidemiological studies and unique material collected from the entirety of Finland. Together with the special advantages of the Finnish population, our existing data and novel methods, such as NSG-based technology, we aim to improve our understanding of prostate cancer biology. Our goals include identification of rare, high-penetrant prostate cancer susceptibility genes  important in the Finnish population as well as common polymorphisms that may have a major significance for the prostate cancer burden at population level. We believe that our results will impact also on diagnostic and therapeutic issues in the future.

Other projects
Genetic predisposition to breast cancer in BRCA1/2 negative families.
Studies on genetic testing of rare monogenic diseases.

Lab members
Elina Kaikkonen
Saana Mönkäre
Hannu-Pekka Schukov
Csilla Sipeky

Group in Tampere:
http://www.uta.fi/ibt/intitute/research/schleutker/index.html

PhD Theses

Sanna Siltanen: Contribution of the ARLTS1 gene to prostate cancer susceptibility, 13.09.2013

Sanna Pakkanen: Profiling of High-risk Prostate Cancer Families in Finland, 12.11.2010

Henna Mattila: Hereditary prostate cancer in Finland: from genetic linkage to susceptibility genes, 11.12.2009

Eija Seppälä: Heterogeneity in Genetic Susceptibility to Prostate Cancer, 1.12.2006

Nina Mononen: Polymorphisms in genes associated with androgen biosynthesis and metabolism as risk factors for human prostate cancer, 4.11.2005

Annika Rökman: In search of high-penetrant prostate cancer susceptibility genes in Finland, 26.11.2004


Publications

2013

Kirsi M. Kuusisto, Oyediran Akinrinade, Mauno Vihinen, Minna Kankuri-Tammilehto, Satu- Leena Laasanen, Johanna Schleutker. Copy Number Variation Analysis in Familial RCA1/2- Negative Finnish Breast and Ovarian Cancer. PLOS ONE 2013 | Volume 8 | Issue 8 | e71802.

Riikka Nurminen , Rainer Lehtonen , Anssi Auvinen , Teuvo L.J. Tammela ,
Tiina Wahlfors , Johanna Schleutker. Fine mapping of 11q13.5 identifies regions ssociated with prostate cancer and prostate cancer death. European Journal of Cancer 2013, 49, 3335 – 3343.

Ali Amin Al Olama, Zsofia Kote-Jara, Fredrick R. Schumacher, Fredrik Wiklund, Sonja I. Berndt, Sara Benlloch, Graham G. Giles, Gianluca Severi, David E. Neal, Freddie C. Hamdy, Jenny L. Donovan, David J. Hunter, Brian E. Henderson, Michael J. Thun, Michael Gaziano, Edward L. Giovannucci, Afshan Siddiq, Ruth C. Travis, David G. Cox, Federico Canzian, Elio Riboli, Timothy J. Key, Gerald Andriole, Demetrius Albanes5, Richard B. Hayes, Johanna Schleutker, Anssi Auvinen30, Teuvo L.J. Tammela31, Maren Weischer33, Janet L. Stanford, Elaine A. Ostrander, Cezary Cybulski, Jan Lubinski, Stephen N. Thibodeau, Daniel J. Schaid, Karina D. Sorensen, Jyotsna Batra, Judith A. Clements, Suzanne Chambers, Joanne Aitken, Robert A. Gardiner, Christiane Maier, Walther Vogel4, Thilo Dörk, Hermann Brenner, Tomonori Habuchi, Sue Ingles,Esther M. John, Joanne L. Dickinson, Lisa Cannon-Albright, Manuel R. Teixeira, Radka Kaneva, Hong-Wei Zhang, Yong-Jie Lu, Jong Y. Park, Kathleen A. Cooney, Kenneth R. Muir, Daniel A. Leongamornlert, Edward Saunders, Malgorzata Tymrakiewicz, Nadiya Mahmud, Michelle Guy, Koveela Govindasami, Lynne T. O’Brien, Rosemary A. Wilkinson, Amanda L. Hall, Emma J.Sawyer, TokhirDadaev, Jonathan Morrison, David P. Dearnaley, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Nicholas Van As, Christopher J. Woodhouse, Alan Thompson,Tim Dudderidge, Chris Ogden, Colin S. Cooper, Artitaya Lophatonanon, Melissa C. Southey, John L. Hopper, Dallas English, Jarmo Virtamo, Loic Le Marchand, Daniele Campa, Rudolf Kaaks, Sara Lindstrom, W. Ryan Diver, Susan Gapstur, Meredith Yeager, AngelaCox, Mariana C. Stern,Roman Corral, Markus Aly, William Isaacs, Jan Adolfsson, Jianfeng Xu, S. Lilly Zheng, Tiina Wahlfors, Kimmo Taari, Paula Kujala, Peter Klarskov, Børge G. Nordestgaard, M. Andreas Røder, Ruth Frikke-Schmidt, Stig E. Bojesen, Liesel M. FitzGerald, Suzanne Kolb, Erika M. Kwon, Danielle M. Karyadi, Torben Falck Orntoft, Michael Borre, Antje Rinckleb, Manuel Luedeke, Kathleen Herkommer, Andreas Meyer, Jurgen Serth, James R.Marthick, Briony Patterson, Dominika Wokolorczyk, Amanda Spurdle, Felicity Lose, Shannon K. McDonnell, Amit D. Joshi, Ahva Shahabi, Pedro Pinto, Joana Santos, Ana Ray, Thomas A. Sellers, Hui-Yi Lin, Robert A. Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher.A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human molecular Genetics 2013; 22(2) 408-415

Sanna Siltanen, Daniel Fischer, Tommi Rantapero, Virpi Laitinen, John Patrick Mpindi,Olli Kallioniemi, Tiina Wahlfors, Johanna Schleutker. ARLTS1 and Prostate Cancer Risk - Analysis of Expression and Regulation. PLOS ONE 2013, Volume 8 | Issue 8 | e72040.

Claire L Simpson, Cheryl D Cropp, Tiina Wahlfors, Asha George, MaryPat S Jones, Ursula Harper, Damaris Ponciano-Jackson, Teuvo Tammela, Johanna Schleutker and Joan E Bailey-Wilson. Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis. European Journal of Human Genetics 2013; 21, 437-443

Hui Shen, Brooke L. Fridley, Honglin Song et al. Epigenetic analysis leads to identification of HNF1B as a subtype-specific susceptibility gene for ovarian cancer. Nature Communications 2013; 4: 1628

Jianfeng Xu, Ethan M. Lange, Lingyi Lu, Siqun L. Zheng, Zhong Wang, Stephen N. Thibodeau, Lisa A. Cannon-Albright , Craig C. Teerlink, Nicola J. Camp, Anna M. Johnson, Kimberly A. Zuhlke, Janet L. Stanford, Elaine A. Ostrander, Kathleen E. Wiley, Sarah D. Isaacs, Patrick C. Walsh, Christiane Maier, Manuel Luedeke, Walther Vogel, Johanna Schleutker, Tiina Wahlfors, Teuvo Tammela, Daniel Schaid, Shannon K. McDonnell, Melissa S. DeRycke, Geraldine Cancel-Tassin, Olivier Cussenot, Fredrik Wiklund, Henrik Grönberg, Ros Eeles,  Doug Easton, Zsofia Kote-Jarai, Alice S. Whittemore,  Chih-Lin Hsieh, Graham G. Giles, John L. Hopper,  Gianluca Severi, William J. Catalona, Diptasri Mandal, Elisa Ledet, William D. Foulkes, Nancy Hamel,  Lovise Mahle, Pal Moller, Isaac Powell,  Joan E. Bailey-Wilson,  John D. Carpten, Daniela Seminara, Kathleen A. Cooney, William B. Isaacs, International Consortium for Prostate Cancer. Genetics.HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG) Hum Genet 2013; 132(1) 5–14

Virpi H. Laitinen, Tiina Wahlfors, Leena Saaristo, et al.
HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk. Cancer Epidemiol  Biomarkers Prev 2013; 22(3)

Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little1, Tokhir Dadaev, David ENeal, Freddie CHamdy, Jenny LDonovan, Ken Muir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Fredrick Schumacher, Brian EHenderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen J Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue A Ingles, Esther M John, Richard B Hayes, Paul DP Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet LStanford, Elaine A Ostrander, Lisa B Signorello, Stephen NThibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Amanda B Spurdle, Judith A Clements4, Manuel R Teixeira, Ed Dicks, Andrew Lee, Alison M Dunning, Caroline Baynes, Don Conroy, Melanie J Maranian, Shahana Ahmed, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas J Van As, Christopher J Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S Cooper, Artitaya Lophatananon, Angela Cox, Melissa C Southey, John L Hopper, Dallas R English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L Zheng, Meredith Yeager, Rudolf Kaaks, WRyan Diver, Mia MGaudet, Mariana C Stern, Roman Corral, Amit D Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L J Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G Nordestgaard, M Andreas Røder, Sune F Nielsen, Stig E Bojesen, Afshan Siddiq, Liesel M FitzGerald, Suzanne Kolb, Erika M Kwon, Danielle M Karyadi, William J Blot, Wei Zheng, Qiuyin Cai, Shannon K McDonnell, Antje E Rinckleb, Bettina Drake, Graham Colditz, Dominika Wokolorczyk, Robert A Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A Sellers, Hui-Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A Cooney, Antonis C Antoniou, Daniel Vincent, François Bacot, Daniel CTessier, The COGS–Cancer Research UKGWAS–ELLIPSE(part of GAME-ON) Initiative, The Australian Prostate Cancer Bioresource, The UKGenetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology, The UKProtecT(Prostate testing for cancer and Treatment) Study Collaborators, The PRACTICAL(Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Zsofia Kote-Jarai & Douglas F Easton. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array Nature Genetics 2013; 45(4)

Zsofia Kote-Jarai, Edward J. Saunders1, Daniel A. Leongamornlert1, Malgorzata Tymrakiewicz, Tokhir Dadaev1, Sarah Jugurnauth-Little, Helen Ross-Adams,  Ali Amin Al Olama, Sara Benlloch, Silvia Halim, Roslin Russel, Alison M. Dunning, Craig Luccarini, Joe Dennis, David E. Neal, Freddie C. Hamdy,  Jenny L. Donovan, Ken Muir, Graham G.Giles, Gianluca Severi,Fredrik Wiklund, Henrik Gronberg, Christopher A. Haiman, Fredrick Schumacher, Brian E. Henderson,  Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J. Hunter, Susan Gapstur, Stephen Chanock, Sonja I. Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J. Key, Ruth C. Travis, Daniele Campa, Sue A. Ingles, Esther M. John, Richard B. Hayes, Paul Pharoah,  Kay-Tee Khaw, Janet L. Stanford,  Elaine A. Ostrander, Lisa B. Signorello, Stephen N. Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S. Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner,  Jong Y. Park, Radka Kaneva, Jyotsna Batra, Amanda Spurdle,  Judith A. Clements, Manuel R. Teixeira, Koveela Govindasami,  Michelle Guy, Rosemary A. Wilkinson, Emma J. Sawyer, Angela Morgan, Ed Dicks, Caroline Baynes, Don Conroy, Stig E. Bojesen, Rudolf Kaaks, Daniel Vincent, Francois Bacot, Daniel C. Tessier, COGS-CRUK GWASELLIPSE (Part of GAME-ON) Initiative}, The UK Genetic Prostate Cancer Study Collaborators/ British Association of Urological Surgeons’ Section of Oncology, The UK ProtecT Study ollaborators, The PRACTICAL Consortium, Douglas F. Easton and Rosalind A. Eeles. Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression. Human Molecular Genetics 2013; 1-9.

Craig C. Teerlink, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Antje Rinckleb, Christiane Maier, Walther Vogel, Geraldine Cancel‑Tassin, Christophe Egrot, Olivier Cussenot, William D. Foulkes, Graham G. Giles, John L. Hopper, Gianluca Severi, Ros Eeles, Douglas Easton, Zsofia Kote‑Jarai, Michelle Guy, Kathleen A. Cooney, Anna M. Ray, Kimberly A. Zuhlke, Ethan M. Lange, Liesel M. FitzGerald, Janet L. Stanford, Elaine A. Ostrander, Kathleen E. Wiley, Sarah D. Isaacs, Patrick C. Walsh, William B. Isaacs, Tiina Wahlfors, Teuvo Tammela, Johanna Schleutker, Fredrik Wiklund, Henrik Gronberg, Monica Emanuelsson, John Carpten , Joan Bailey‑Wilson, Alice S. Whittemore, Ingrid Oakley‑Girvan, Chih‑Lin Hsieh, William J. Catalona, S. Lilly Zheng, Guangfu Jin, Lingyi Lu,
Jianfeng Xu, International Consortium for Prostate Cancer Genetics, Nicola J. Camp, Lisa A. Cannon‑Albright. Association analysis of 9,560 prostate cancer cases from the
International Consortium of Prostate Cancer Genetics confirms the role of reported prostate cancer associated SNPs for familial disease. Hum Genet 2013, DOI 10.1007/s00439-013-1384-2.


2012
Pelttari LM, Nurminen R, Gylfe A, Aaltonen LA, Schleutker J, Nevanlinna H. Screening of Finnish RAD51C founder mutations in prostate and colorectal cancer patients. BMC Cancer 2012; 12(1)552.

Amin Al Olama A, Kote-Jarai Z, Schumacher FR, Wiklund F, Berndt SI, Benlloch S, Giles GG, Severi G, Neal DE, Hamdy FC, Donovan JL, Hunter DJ, Henderson BE, Thun MJ, Gaziano M, Giovannucci EL, Siddiq A, Travis RC, Cox DG, Canzian F, Riboli E, Key TJ, Andriole G, Albanes D, Hayes RB, Schleutker J, Auvinen A, Tammela TL, Weischer M, Stanford JL, Ostrander EA, Cybulski C, Lubinski J, Thibodeau SN, Schaid DJ, Sorensen KD, Batra J, Clements JA, Chambers S, Aitken J, Gardiner RA, Maier C, Vogel W, Dörk T, Brenner H, Habuchi T, Ingles S, John EM, Dickinson JL, Cannon-Albright L, Teixeira MR, Kaneva R, Zhang HW, Lu YJ, Park JY, Cooney KA, Muir KR, Leongamornlert DA, Saunders E, Tymrakiewicz M, Mahmud N, Guy M, Govindasami K, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Dudderidge T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English D, Virtamo J, Le Marchand L, Campa D, Kaaks R, Lindstrom S, Diver WR, Gapstur S, Yeager M, Cox A, Stern MC, Corral R, Aly M, Isaacs W, Adolfsson J, Xu J, Zheng SL, Wahlfors T, Taari K, Kujala P, Klarskov P, Nordestgaard BG, Røder MA, Frikke-Schmidt R, Bojesen SE, Fitzgerald LM, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Rinckleb A, Luedeke M, Herkommer K, Meyer A, Serth J, Marthick JR, Patterson B, Wokolorczyk D, Spurdle A, Lose F, McDonnell SK, Joshi AD, Shahabi A, Pinto P, Santos J, Ray A, Sellers TA, Lin HY, Stephenson RA, Teerlink C, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V, Chanock S, Gronberg H, Haiman CA, Kraft P, Easton DF, Eeles RA. A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease., Hum Mol Genet 2012, in press.

Xu J, Lange EM, Lu L, Zheng SL, Wang Z, Thibodeau SN, Cannon-Albright LA, Teerlink CC, Camp NJ, Johnson AM, Zuhlke KA, Stanford JL, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Maier C, Luedeke M, Vogel W, Schleutker J, Wahlfors T, Tammela T, Schaid D, McDonnell SK, Derycke MS, Cancel-Tassin G, Cussenot O, Wiklund F, Grönberg H, Eeles R, Easton D, Kote-Jarai Z, Whittemore AS, Hsieh CL, Giles GG, Hopper JL, Severi G, Catalona WJ, Mandal D, Ledet E, Foulkes WD, Hamel N, Mahle L, Moller P, Powell I, Bailey-Wilson JE, Carpten JD, Seminara D, Cooney KA, Isaacs WB. HOXB13 is a susceptibility gene for prostate cancer: results from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet 2012, in press.

Simpson CL, Cropp CD, Wahlfors T, George A, Jones MS, Harper U, Ponciano-Jackson D, Tammela T, Schleutker J, Bailey-Wilson JE. Genetic heterogeneity in Finnish hereditary prostate cancer using ordered subset analysis. Eur J Hum Genet 2012, in press.

Kouprina N, Lee NC, Pavlicek A, Samoshkin A, Kim JH, Lee HS, Varma S, Reinhold WC, Otstot J, Solomon G, Davis S, Meltzer PS, Schleutker J, Larionov V. Exclusion of the 750-kb genetically unstable region at Xq27 as a candidate locus for prostate malignancy in HPCX1-linked families. Genes Chromosomes Cancer 2012 ;51(10)933-48.

Bailey-Wilson JE, Childs EJ, Cropp CD, Schaid DJ, Xu J, Camp NJ, Cannon-Albright LA, Farnham JM, George A, Powell I, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Mæhle L, Møller P, Eeles R, Easton D, Guy M, Edwards S, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Stanford JL, Karyadi DM, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Thibodeau SN, McDonnell SK, Hebbring S, Lange EM, Cooney KA, Tammela TLj, Schleutker J, Maier C, Bochum S, Hoegel J, Grönberg H, Wiklund F, Emanuelsson M, Cancel-Tassin G, Valeri A, Cussenot O, Isaacs WB. Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families. BMC Med Genet 2012;1346.

Pelttari LM, Kiiski J, Nurminen R, Kallioniemi A, Schleutker J, Gylfe A, Aaltonen LA, Leminen A, Heikkilä P, Blomqvist C, Bützow R, Aittomäki K, Nevanlinna H. A Finnish founder mutation in RAD51D: analysis in breast, ovarian, prostate, and colorectal cancer. J Med Genet 2012;49(7)429-32.

Jin G, Lu L, Cooney KA, Ray AM, Zuhlke KA, Lange EM, Cannon-Albright LA, Camp NJ, Teerlink CC, Fitzgerald LM, Stanford JL, Wiley KE, Isaacs SD, Walsh PC, Foulkes WD, Giles GG, Hopper JL, Severi G, Eeles R, Easton D, Kote-Jarai Z, Guy M, Rinckleb A, Maier C, Vogel W, Cancel-Tassin G, Egrot C, Cussenot O, Thibodeau SN, McDonnell SK, Schaid DJ, Wiklund F, Grönberg H, Emanuelsson M, Whittemore AS, Oakley-Girvan I, Hsieh CL, Wahlfors T, Tammela T, Schleutker J, Catalona WJ, Zheng SL, Ostrander EA, Isaacs WB, Xu J. Validation of prostate cancer risk-related loci identified from genome-wide association studies using family-based association analysis: evidence from the International Consortium for Prostate Cancer Genetics (ICPCG). Hum Genet 2012;131(7)1095-103.

Schleutker J. Polymorphisms in androgen signaling pathway predisposing to prostate cancer.Mol Cell Endocrinol 2012;360(1-2)25-37.

Lu L, Cancel-Tassin G, Valeri A, Cussenot O, Lange EM, Cooney KA, Farnham JM, Camp NJ, Cannon-Albright LA, Tammela TL, Schleutker J, Hoegel J, Herkommer K, Maier C, Vogel W, Wiklund F, Emanuelsson M, Grönberg H, Wiley KE, Isaacs SD, Walsh PC, Helfand BT, Kan D, Catalona WJ, Stanford JL, FitzGerald LM, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Whittemore AS, Oakley-Girvan I, Hsieh CL, Powell I, Bailey-Wilson JE, Cropp CD, Simpson C, Carpten JD, Seminara D, Zheng SL, Xu J, Giles GG, Severi G, Hopper JL, English DR, Foulkes WD, Maehle L, Moller P, Badzioch MD, Edwards S, Guy M, Eeles R, Easton D, Isaacs WB. Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. Prostate 2012;72(4)410-26.

Pakkanen S, Kujala PM, Ha N, Matikainen MP, Schleutker J, Tammela TL. Clinical and histopathological characteristics of familial prostate cancer in Finland. BJU Int 2012;109(4)557-63.
 

2011
Siltanen S, Wahlfors T, Schindler M, Saramäki OR, Mpindi JP, Latonen L, Vessella RL, Tammela TL, Kallioniemi O, Visakorpi T, Schleutker J. Contribution of ARLTS1 Cys148Arg (T442C) variant with prostate cancer risk and ARLTS1 function in prostate cancer cells. PLoS One 2011;6(10)e26595.

Mattila H, Schindler M, Isotalo J, Ikonen T, Vihinen M, Oja H, Tammela TL, Wahlfors T, Schleutker J. NMD and microRNA expression profiling of the HPCX1 locus reveal MAGEC1 as a candidate prostate cancer predisposition gene. BMC Cancer 2011;11327

Kote-Jarai Z, Olama AA, Giles GG, Severi G, Schleutker J, Weischer M, Campa D, Riboli E, Key T, Gronberg H, Hunter DJ, Kraft P, Thun MJ, Ingles S, Chanock S, Albanes D, Hayes RB, Neal DE, Hamdy FC, Donovan JL, Pharoah P, Schumacher F, Henderson BE, Stanford JL, Ostrander EA, Sorensen KD, Dörk T, Andriole G, Dickinson JL, Cybulski C, Lubinski J, Spurdle A, Clements JA, Chambers S, Aitken J, Gardiner RA, Thibodeau SN, Schaid D, John EM, Maier C, Vogel W, Cooney KA, Park JY, Cannon-Albright L, Brenner H, Habuchi T, Zhang HW, Lu YJ, Kaneva R, Muir K, Benlloch S, Leongamornlert DA, Saunders EJ, Tymrakiewicz M, Mahmud N, Guy M, O'Brien LT, Wilkinson RA, Hall AL, Sawyer EJ, Dadaev T, Morrison J, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Lophatonanon A, Southey MC, Hopper JL, English DR, Wahlfors T, Tammela TL, Klarskov P, Nordestgaard BG, Røder MA, Tybjærg-Hansen A, Bojesen SE, Travis R, Canzian F, Kaaks R, Wiklund F, Aly M, Lindstrom S, Diver WR, Gapstur S, Stern MC, Corral R, Virtamo J, Cox A, Haiman CA, Le Marchand L, Fitzgerald L, Kolb S, Kwon EM, Karyadi DM, Orntoft TF, Borre M, Meyer A, Serth J, Yeager M, Berndt SI, Marthick JR, Patterson B, Wokolorczyk D, Batra J, Lose F, McDonnell SK, Joshi AD, Shahabi A, Rinckleb AE, Ray A, Sellers TA, Lin HY, Stephenson RA, Farnham J, Muller H, Rothenbacher D, Tsuchiya N, Narita S, Cao GW, Slavov C, Mitev V, Easton DF, Eeles RA. Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study. Nat Genet 2011;43(8)785-91.

Pelttari LM, Heikkinen T, Thompson D, Kallioniemi A, Schleutker J, Holli K, Blomqvist C, Aittomäki K, Bützow R, Nevanlinna H. RAD51C is a susceptibility gene for ovarian cancer. Hum Mol Genet 2011;20(16)3278-88.

Kuusisto KM, Bebel A, Vihinen M, Schleutker J, Sallinen SL. Screening for BRCA1, BRCA2, CHEK2, PALB2, BRIP1, RAD50, and CDH1 mutations in high-risk Finnish BRCA1/2-founder mutation-negative breast and/or ovarian cancer individuals. Breast Cancer Res 2011;13(1)R20.


Cropp CD, Simpson CL, Wahlfors T, Ha N, George A, Jones MS, Harper U, Ponciano-Jackson D, Green TA, Tammela TL, Bailey-Wilson J, Schleutker J. Genome-wide linkage scan for prostate cancer susceptibility in Finland: evidence for a novel locus on 2q37.3 and confirmation of signal on 17q21-q22.Int J Cancer 2011;129(10)2400-7.

Nurminen R, Wahlfors T, Tammela TL, Schleutker J. Identification of an aggressive prostate cancer predisposing variant at 11q13.Int J Cancer 2011;129(3)599-606.

 
2010
Christensen GB, Baffoe-Bonnie AB, George A, Powell I, Bailey-Wilson JE, Carpten JD, Giles GG, Hopper JL, Severi G, English DR, Foulkes WD, Maehle L, Moller P, Eeles R, Easton D, Badzioch MD, Whittemore AS, Oakley-Girvan I, Hsieh CL, Dimitrov L, Xu J, Stanford JL, Johanneson B, Deutsch K, McIntosh L, Ostrander EA, Wiley KE, Isaacs SD, Walsh PC, Isaacs WB, Thibodeau SN, McDonnell SK, Hebbring S, Schaid DJ, Lange EM, Cooney KA, Tammela TL, Schleutker J, Paiss T, Maier C, Grönberg H, Wiklund F, Emanuelsson M, Farnham JM, Cannon-Albright LA, Camp NJ. Genome-wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for Prostate Cancer Genetics using novel sumLINK and sumLOD analyses. Prostate 2010;70(7)735-44.

 
2009
Pakkanen S, Wahlfors T, Siltanen S, Patrikainen M, Matikainen MP, Tammela TL, Schleutker J. PALB2 variants in hereditary and unselected Finnish prostate cancer cases. J Negat Results Biomed 2009;812.

Pakkanen S, Pukkala E, Kainulainen H, Matikainen MP, Koivisto PA, Tammela TL, Schleutker J. Incidence of cancer in finnish families with clinically aggressive and nonaggressive prostate cancer. Cancer Epidemiol Biomarkers Prev 2009;18(11)3049-56.

Gudmundsson J, Sulem P, Gudbjartsson DF, Blondal T, Gylfason A, Agnarsson BA, Benediktsdottir KR, Magnusdottir DN, Orlygsdottir G, Jakobsdottir M, Stacey SN, Sigurdsson A, Wahlfors T, Tammela T, Breyer JP, McReynolds KM, Bradley KM, Saez B, Godino J, Navarrete S, Fuertes F, Murillo L, Polo E, Aben KK, van Oort IM, Suarez BK, Helfand BT, Kan D, Zanon C, Frigge ML, Kristjansson K, Gulcher JR, Einarsson GV, Jonsson E, Catalona WJ, Mayordomo JI, Kiemeney LA, Smith JR, Schleutker J, Barkardottir RB, Kong A, Thorsteinsdottir U, Rafnar T, Stefansson K. Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility. Nat Genet 2009;41(10)1122-6.

Eeles RA, Kote-Jarai Z, Al Olama AA, Giles GG, Guy M, Severi G, Muir K, Hopper JL, Henderson BE, Haiman CA, Schleutker J, Hamdy FC, Neal DE, Donovan JL, Stanford JL, Ostrander EA, Ingles SA, John EM, Thibodeau SN, Schaid D, Park JY, Spurdle A, Clements J, Dickinson JL, Maier C, Vogel W, Dörk T, Rebbeck TR, Cooney KA, Cannon-Albright L, Chappuis PO, Hutter P, Zeegers M, Kaneva R, Zhang HW, Lu YJ, Foulkes WD, English DR, Leongamornlert DA, Tymrakiewicz M, Morrison J, Ardern-Jones AT, Hall AL, O'Brien LT, Wilkinson RA, Saunders EJ, Page EC, Sawyer EJ, Edwards SM, Dearnaley DP, Horwich A, Huddart RA, Khoo VS, Parker CC, Van As N, Woodhouse CJ, Thompson A, Christmas T, Ogden C, Cooper CS, Southey MC, Lophatananon A, Liu JF, Kolonel LN, Le Marchand L, Wahlfors T, Tammela TL, Auvinen A, Lewis SJ, Cox A, FitzGerald LM, Koopmeiners JS, Karyadi DM, Kwon EM, Stern MC, Corral R, Joshi AD, Shahabi A, McDonnell SK, Sellers TA, Pow-Sang J, Chambers S, Aitken J, Gardiner RA, Batra J, Kedda MA, Lose F, Polanowski A, Patterson B, Serth J, Meyer A, Luedeke M, Stefflova K, Ray AM, Lange EM, Farnham J, Khan H, Slavov C, Mitkova A, Cao G, Easton DF. Identification of seven new prostate cancer susceptibility loci through a genome-wide association study. Nat Genet 2009;41(10)1116-21.

Mononen N, Schleutker J. Polymorphisms in genes involved in androgen pathways as risk factors for prostate cancer. J Urol 2009;181(4)1541-9.

 
2008
Kote-Jarai Z, Easton DF, Stanford JL, Ostrander EA, Schleutker J, Ingles SA, Schaid D, Thibodeau S, Dörk T, Neal D, Donovan J, Hamdy F, Cox A, Maier C, Vogel W, Guy M, Muir K, Lophatananon A, Kedda MA, Spurdle A, Steginga S, John EM, Giles G, Hopper J, Chappuis PO, Hutter P, Foulkes WD, Hamel N, Salinas CA, Koopmeiners JS, Karyadi DM, Johanneson B, Wahlfors T, Tammela TL, Stern MC, Corral R, McDonnell SK, Schürmann P, Meyer A, Kuefer R, Leongamornlert DA, Tymrakiewicz M, Liu JF, O'Mara T, Gardiner RA, Aitken J, Joshi AD, Severi G, English DR, Southey M, Edwards SM, Al Olama AA, Eeles RA. Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium. Cancer Epidemiol Biomarkers Prev 2008;17(8)2052-61.

Siltanen S, Syrjäkoski K, Fagerholm R, Ikonen T, Lipman P, Mallott J, Holli K, Tammela TL, Järvinen HJ, Mecklin JP, Aittomäki K, Blomqvist C, Bailey-Wilson JE, Nevanlinna H, Aaltonen LA, Schleutker J, Vahteristo P. ARLTS1 germline variants and the risk for breast, prostate, and colorectal cancer. Eur J Hum Genet 2008;16(8)983-91.

Vaarala MH, Mattila H, Ohtonen P, Tammela TL, Paavonen TK, Schleutker J. The interaction of CYP3A5 polymorphisms along the androgen metabolism pathway in prostate cancer. Int J Cancer 2008;122(11)2511-6.

 



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