Anne Roivainen profile picture
Anne
Roivainen
Professor, Turku PET Centre
Professor, Turku PET Centre
Professor of Preclinical Imaging and Drug Research

Contact

+358 40 824 3510
Kiinamyllynkatu 4-8
20520
Turku

Links

Roivainen Group
Researchgate
LinkedIn
ORCID

Areas of expertise

Molecular Imaging
PET
Inflammation Imaging

Research

http://inflammation-imaging.utu.fi

Our group is based in Turku PET Centre, University of Turku and Turku University Hospital. Our research focuses on developing radiopharmaceuticals for the PET imaging of various inflammatory diseases.

Inflammation is a significant component of several chronic diseases involving the cardiovascular, metabolic, respiratory, gastro-intestinal, musculoskeletal and nervous systems. Positron emission tomography (PET) with targeted probes enables evaluation of the molecular and cellular pathophysiological mechanisms of diseases (i.e. molecular imaging). However, more specific markers than the currently used glucose analogue, fluorodeoxyglucose 18F-FDG, are needed to assess inflammation and its consequences in different pathologies. Aims of our studies are pre-clinical evaluation of new targeted probes and techniques for molecular imaging of inflammation. The imaging agents will be evaluated in experimental models of inflammation, in healthy subjects and in patients. The main hypothesis is that sensitive whole-body imaging of inflammation will enable early diagnosis, help in patient selection to particular therapy and monitor therapy outcome. Noteworthy, the development of new radiopharmaceuticals requires several years’ effort and expensive proof-of-concept and acute toxicity studies. Our research is focusing on PET tracers and to lesser extent magnetic resonance (MR) and single-photon emission computed tomography (SPECT) imaging agents.


Publications

Sort by:

Cardiac Metabolic Pathway Remodelling in Response to Sunitinib Malate: Potential Role for Positron Emission Tomography in the Cardio-Oncology Setting (conference abstract) (2016)

Irish Journal of Medical Science
O’Farrell AC, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray D, Jarzabek MA, Maratha A,
Alamanou M, Mallya Udupi G, Shiels L, Pallaud C, Saraste A, Liljenba¨ck H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, McAuliffe FM, Rousseau JA, Lecomte R, Gascon S, Ky B, Force T, Knuuti J, Gallagher W, Roivainen A, Byrne AT
(Muu (O2))

Feasibility of 68Ga-labeled Siglec-9 peptide for the imaging of acute lung inflammation: a pilot study in a porcine model of acute respiratory distress syndrome (2016)

American Journal of Nuclear Medicine and Molecular Imaging
Jaime Retamal, Jens Sörensen, Mark Lubberink, Fernando Suarez-Sipmann, João Batista Borges, Ricardo Feinstein, Sirpa Jalkanen, Gunnar Antoni, Göran Hedenstierna, Anne Roivainen, Anders Larsson, Irina Velikyan
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Mitochondrial DNA Replication Defects Disturb Cellular dNTP Pools and Remodel One-Carbon Metabolism (2016)

Cell Metabolism
Nikkanen J, Forsstrom S, Euro L, Paetau I, Kohnz RA, Wang LY, Chilov D, Viinamaki J, Roivainen A, Marjamaki P, Liljenback H, Ahola S, Buzkova J, Terzioglu M, Khan NA, Pirnes-Karhu S, Paetau A, Lonnqvist T, Sajantila A, Isohanni P, Tyynismaa H, Nomura DK, Battersby BJ, Velagapudi V, Carroll CJ, Suomalainen A
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
People search