Gautier Follain profile picture

Gautier
Follain

Docent, Department of Life Technologies
Postdoctoral Researcher, Turku Bioscience Centre

Areas of expertise

Cell Biology
Cancer biology
Biophysics.

Biography

I did a PhD in life science in the lab. of Dr. Jacky Goetz (Strasbourg). I studied the role of blood flow forces on arrest, adhesion and extravasation of circulating breast/mammary cells, using multiple imaging modalities, mostly applied to microfluidics and zebrafish embryos. I described endothelial remodeling around arrested tumor cells as an extravasation mechanism of cancer cells (Follain et al. Dev cell 2018). Our works demonstrated that not only size exclusion but also shear forces are biophysic parameters driving the metastatic spreading (Follain et al. NRC 2020).
I moved to Turku in 2020 as a shared postdoc between the Cell Adhesion and Cancer lab of Prof. J. Ivaska and the lab of Dr. G. Jacquemet focusing on cellular protrusion and Cell Migration. I used similar models to study the metastatic cascade of Pancreatic Ductal AdenoCarcinoma.

Research

Main focus : Studying the metastatic spreading of Pancreatic Ductal AdenoCarcinoma.

Publications

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Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells (2026)

Nature Materials
Gensbittel, Valentin; Yesilata, Zeynep; Bochler, Louis; Follain, Gautier; Nemoz-Billet, Laurie; Lefebvre, Olivier; Uhlmann, Klemens; Larnicol, Annabel; Ammirati, Giulia E. M.; Harlepp, Sébastien; Goswami, Ruchi; Girardo, Salvatore; Paulen, Laetitia; Hyenne, Vincent; Mittelheisser, Vincent; Stemmelen, Tristan; Molitor, Anne; Carapito, Raphael; Belthier, Guillaume; Pannequin, Julie; Kräter, Martin; Müller, Daniel J.; Balzani, Daniel; Guck, Jochen; Osmani, Naël; Goetz, Jacky G.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Time, the final frontier (2025)

Molecular Oncology
Follain, Gautier; Dibus, Michal; Joshi, Omkar; Jacquemet, Guillaume
(B1 Vertaisarvioitu muu artikkeli (esim. pääkirjoitus, letter, comment) tieteellisessä lehdessä)

Platelets favor the outgrowth of established metastases (2024)

Nature Communications
Garcia-Leon Maria J., Liboni Cristina, Mittelheisser Vincent, Bochler Louis, Follain Gautier, Mouriaux Clarisse, Busnelli Ignacio, Larnicol Annabel, Colin Florent, Peralta Marina, Osmani Naël, Gensbittel Valentin, Bourdon Catherine, Samaniego Rafael, Pichot Angélique, Paul Nicodème, Molitor Anne, Carapito Raphaël, Jandrot-Perrus Martine, Lefebvre Olivier, Mangin Pierre H., Goetz Jacky G.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

TLNRD1 is a CCM complex component and regulates endothelial barrier integrity (2024)

Journal of Cell Biology
Ball, Neil J.; Ghimire, Sujan; Follain, Gautier; Pajari, Ada O.; Wurzinger, Diana; Vaitkevičiūtė, Monika; Cowell, Alana R.; Berki, Bence; Ivaska, Johanna; Paatero, Ilkka; Goult, Benjamin T.; Jacquemet, Guillaume
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )