Gennadi Egutkin profile picture

Gennadi
Egutkin

Senior Research Fellow, MediCity
Docent, Institute of Biomedicine
PhD, Docent

Contact

+358 29 450 4388
Tykistökatu 6
20520
Turku

Biography

Education and degrees completed

December 2008: Docent tenure (Adjunct Professor) at the Faculty of Medicine, University of Turku (UTU) in the area of “Enzyme immunology” (Diploma #746/141/2008)

October 1989: Candidate of Biological Sciences (equivalent to PhD) in Biochemistry & Endocrinology. Institute of Endocrinology and Metabolism, Kiev, Ukraine

1984 – 1987: Postgraduate Student. Institute of Radiobiology, Academy of Sciences of Belarus, Minsk, Belarus

1979 – 1984: Master of Science. Faculty of Biology, Department of Biochemistry, Belarus State University, Minsk, Belarus (finished with excellence)

Current employment and previous work experience

1998 – present: Senior Scientist, Docent, MediCity Research Laboratory, UTU, Finland. 

1997 – 1998: Senior Research Fellow, Royal Free Hospital, University College London, England.

1987 – 1997: Scientific Researcher, Institute of Radiobiology, Academy of Sciences of Belarus, Minsk, Republic of Belarus.

Teaching

Principal supervisor (PS) or co-supervisor (co-S) for: Bachelor’s thesis of Camilla Tallgren (Turku University of Applied Sciences; May 2011, PS) Master of Science (MSc) thesis of Mikko Helenius (UTU; March 2011, PS) PhD thesis of Mariachiara Zuccarini (University of Chieti-Pescara, Italy; April 2015, PS) PhD thesis of Mikko Helenius (University of Helsinki; October 2015, co-S) MSc thesis of Marius Paul (University of Bonn [UB], Germany; May 2019, PS) MSc thesis of Nora Kreisig (UB, September 2024, PS) MSc thesis of Samuel Svärd (UTU; November 2024, PS) PhD thesis of Karolina Losenkova (UTU; March 2025, PS) MSc thesis of Julia Baier (UB, April 2026, PS) MSc thesis of Ursula von Danwitz (UB, PS). Currently, I am supervising PhD Theses of Samuel Svärd (UTU, PS) and Shaghayegh Hasanpour (UTU, co-S).

The following visiting researchers, undergraduate and PhD students received training in MediCity under my supervision: Dr. Nathalie Mercier (Nancy, France; 2008–2010) Anne Meyer (UB, April–June 2014) Justyna Kowal (University of Copenhagen, Denmark, December 2014) Mariachiara Zuccarini (University of Chieti-Pescara, Italy, September 2014 – February 2015) Valeria Quarona (University of Torino, Italy, April 2015) Octavia Cadassou (University of Lyon, France, January – February 2017) Karolina Losenkova (Moscow Institute of Physics, Russia, October 2015 – November 2017) Julian Zeiner (UB, May – October 2017) Marius Paul (UB, January – May 2018) • Corinna Weiler (UB, May – October 2021) • Nora Kreisig (UB, May – October 2023) • Joanna Pomeroy (University of Portsmouth, UK, July 2024) Ursula Johanna von Danwitz (UB, May – October 2025) Julia Baier (UB, July 2025 – February 2026) Johanna Beining (UB, June – November 2026).

Lecturing activity: oral presentations and invited lectures (selected from the last 5 years)

  • University of Iceland, Reykjavik, Iceland (June 2022).  
  • 3rd International Meeting of Purinergic Signaling, Buzios, Brazil (September 2022).
  • 1st eCOST PRESTO meeting, Ferrara, Italy (February 2023)
  • University of Portsmouth, Portsmouth, The United Kingdom (April 2023).
  • 2nd eCOST PRESTO meeting, Pisa, Italy (September 2023)
  • 2nd Adenosine-Pathway Cancer Immunotherapy Summit, Boston, USA (June 2023)
  • Duke University School of Medicine, Durham, USA (June 2023).
  • University Medical Center Hamburg-Eppendorf, Hamburg, Germany (November 2023).  
  • University of Coimbra, Coimbra, Portugal (March 2024)
  • University of Bonn, Bonn, Germany (July 2024)
  • 2nd European Purine Meeting, Ferrara, Italy (September 2024)
  • 4th eCOST PRESTO meeting, Dublin, Ireland (May 2025)
  • 5th eCOST PRESTO meeting, Portsmouth, The United Kingdom (February 2026)
  • 3rd European Purine Meeting, Bordeaux, France (July 2026)

Along with a primary focus on supervising research and student training, I gave an annual course of topical lectures to student of the Medical Faculty (UTU, Finland) in 2008-2022.

Research

My research focus for the past 25 years has been to investigate cellular metabolism in various pathophysiological states. I have especially contributed to the papers dealing with role of purine-converting enzymes in cancer, inflammation and vascular remodelling. Overall, I have >100 publications including six Invited Review Articles and four Book Chapters. These papers have been cited 6100 times (h-index 43; Web of Science™).

2010 – 2018: My Review (Yegutkin, Biochim Biophys Acta, 2008) was ranked as a “highly cited paper” in the top 1% in the field of Molecular Biology & Genetics (984 citations, Web of Science™) 2025: Our Review (Yegutkin & Boison, Pharm Rev, 2022) was ranked as a “hot paper” in the top 0.1% in the field of Pharmacology & Toxicology (148 citations).

Publications

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Fluorine‐18‐Labeled Nucleotide Analogs Targeting Ecto‐5'‐Nucleotidase (CD73) for Positron Emission Tomography Imaging of Solid Tumors (2026)

Angewandte Chemie International Edition
Dobelmann, Clemens; Schmies, Constanze C.; Rolshoven, Georg Wilhelm; Scortichini, Mirko; Wagner, Stefan; Isaak, Andreas; Idris, Riham M.; Dabel, Jennifer; Grey, Lucie; Losenkova, Karolina; Moschutz, Susanne; Al Hroub, Haneen; Keim, Antje; Hoppner, Sandra; Sandholm, Jouko; Bostrom, Pia; Hollmen, Maija; Strater, Norbert; Hermann, Sven; Yegutkin, Gennady G.; Jacobson, Kenneth A.; Schelhaas, Sonja; Muller, Christa E.; Junker, Anna
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Methodological guidelines for P2X receptor assays and data interpretation (2026)

Cell Death and Disease
Gorecki, Dariusz C.; Adinolfi, Elena; Adriouch, Sahil; Coutinho-Silva, Robson; Engel, Tobias; Gölöncsér, Flóra; Haag, Friedrich; Illes, Peter; Jacobson, Kenneth A.; Koch-Nolte, Friedrich; Mansoor, Steven E.; Matute, Carlos; Melino, Gerry; Novak, Ivana; Pegoraro, Anna; Pelegrin, Pablo; Piacentini, Mauro; Robson, Simon C.; Rumney, Robin M. H.; Seman, Michel; Sluyter, Ronald; Sperlagh, Beáta; Tang, Yong; Tarantini, Mario; Ulrich, Henning; Vouret-Craviari, Valerie; Ye, Qing; Yegutkin, Gennady G.; Verkhratsky, Alexei
(A2 Vertaisarvioitu katsausartikkeli tieteellisessä lehdessä)

Spatiotemporal diversity in molecular and functional abnormalities in the mdx dystrophic brain (2025)

Molecular Medicine
Pomeroy, Joanna; Borczyk, Malgorzata; Kawalec, Maria; Hajto, Jacek; Carlson, Emma; Svärd, Samuel; Verma, Suraj; Bareke, Eric; Boratyńska-Jasińska, Anna; Dymkowska, Dorota; Mellado-Ibáñez, Alvaro; Laight, David; Zabłocki, Krzysztof; Occhipinti, Annalisa; Majewska, Loydie; Angione, Claudio; Majewski, Jacek; Yegutkin, Gennady G.; Korostynski, Michal; Zabłocka, Barbara; Górecki, Dariusz C.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Structure-Activity Relationship of 3-Methylcytidine-5 '-alpha,beta-methylenediphosphates as CD73 Inhibitors (2022)

Journal of Medicinal Chemistry
Scortichini Mirko, Idris Riham Mohammed, Moschutz Susanne, Keim Antje, Salmaso Veronica, Dobelmann Clemens, Oliva Paola, Losenkova Karolina, Irjala Heikki, Vaittinen Samuli, Sandholm Jouko, Yegutkin Gennady G, Sträter Norbert, Junker Anna, Müller Christa E, Jacobson Kenneth A
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

CD73 controls ocular adenosine levels and protects retina from light-induced phototoxicity (2022)

Cellular and Molecular Life Sciences
Losenkova Karolina, Takeda Akira, Ragauskas Symantas, Cerrada-Gimenez Marc, Vähätupa Maria, Kaja Simon, Paul Marius L., Schmies Constanze C., Rolshoven Georg, Müller Christa E., Sandholm Jouko, Jalkanen Sirpa, Kalesnykas Giedrius, Yegutkin Gennady G.
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )