Gennadi Egutkin

Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)

ACS Medicinal Chemistry Letters

Schmies CC, Rolshoven G, Idris RM, Losenkova K, Renn C, Schakel L, Al-Hroub H, Wang YL, Garofano F, Schmidt-Wolf IGH, Zimmermann H, Yegutkin GG, Muller CE

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)

Journal of Cell Science

Losenkova K, Zuccarini M, Karikoski M, Laurila J, Boison D, Jalkanen S, Yegutkin GG

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation (2019)

Cancer Research

Lerner AG, Kovalenko M, Welch M, Dela Cruz T, Jones J, Wong C, Spatola B, Eberhardt M, Wong A, Fung W, Lagpacan L, Losenkova K, Yegutkin G, Soros V, Corbin J, Beers C, Moesta AK, Moesta AK

(Muu (O2))

Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5 '-Nucleotidase (CD73) Inhibitors (2019)

Journal of Medicinal Chemistry

Junker A., Renn C., Dobelmann C., Namasivayam V., Jain S., Losenkova K., Irjala H., Duca S., Balasubramanian R., Chakraborty S., Börgel F., Zimmermann H., Yegutkin G.G., Müller C.E., Jacobson K.A.

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019)

Cancer Cell

Detlev Boison, Gennady Yegutkin

(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 '-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy (2019)

Advanced therapeutics

Sanjay Bhattarai, Jan Pippel, Anne Meyer, Marianne Freundlieb, Constanze Schmies, Aliaa Abdelrahman, Amelie Fiene, Sang-Yong Lee, Herbert Zimmermann, Ali El-Tayeb, Gennady G. Yegutkin, Norbert Sträter, Christa E. Muller

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)

Journal of Molecular Medicine

Julian Zeiner, Sirpa Loukovaara, Karolina Losenkova, Mariachiare Zuccarini, Ani M. Korhonen, Kaisa Lehti, Anu Kauppinen, Kai Kaarniranta, Christa E. Muller, Sirpa Jalkanen, Gennady G. Yegutkin

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)

BBA - Molecular Basis of Disease

Karolina Losenkova, Mariachiara Zuccarini, Mikko Helenius, Guillaume Jacquemet, Evgenia Gerasimovskaya, Camilla Tallgren, Sirpa Jalkanen, Gennady G. Yegutkin

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73 (2018)

Purinergic Signalling

Losenkova K, Zeiner J, Kukkonen-Macchi A, Algars A, Sundstrom J, Jalkanen S, Yegutkin GG

(Muu (O2))

Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum (2018)

Journal of Investigative Dermatology

Gilles Kauffenstein, Gennady G. Yegutkin, Salim Khiati, Viola Pomozi, Olivier Le Saux, Georges Leftheriotis, Guy Lenaers, Daniel Henrion, Ludovic Martin

(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

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Fluorescent Probes for Ecto-5 '-nucleotidase (CD73) (2020)

Compartmentalization of adenosine metabolism in cancer cells and its modulation during acute hypoxia (2020)

Targeting CD39 with a first-in-class inhibitory antibody prevents ATP processing and increases T-cell activation (2019)

Structure-Activity Relationship of Purine and Pyrimidine Nucleotides as Ecto-5 '-Nucleotidase (CD73) Inhibitors (2019)

Adenosine Metabolism: Emerging Concepts for Cancer Therapy (2019)

X-Ray Co-Crystal Structure Guides the Way to Subnanomolar Competitive Ecto-5 '-Nucleotidase (CD73) Inhibitors for Cancer Immunotherapy (2019)

Soluble and membrane-bound adenylate kinase and nucleotidases augment ATP-mediated inflammation in diabetic retinopathy eyes with vitreous hemorrhage (2019)

Endothelial cells cope with hypoxia-induced depletion of ATP via activation of cellular purine turnover and phosphotransfer networks (2018)

Regulation of intratumoral purine homeostasis and signaling via concerted action of alkaline phosphatases, CD39 and CD73 (2018)

Alteration of Extracellular Nucleotide Metabolism in Pseudoxanthoma Elasticum (2018)