Hidehiro Iida profile picture

Hidehiro
Iida

Turku PET Centre
PhD in Physics from Univ of Tsukuba, PhD in Medical science from Tohoku Univ

Areas of expertise

Instrumentation and modeling in PET
SPECT and medical imaging

Biography

Dr. Hidehiro Iida has received PhD in Physics (Experimental Nuclear Physics) by the nuclear reaction mechanism in 1984, in which 2nd Born approximation formulation was verified based on hyper-polarized proton accelerated beams introducing (p,t) reactions. He has also contributed to develop a unique position-sensitive detector. He then joined a team at Research Institute for Brain and Blood Vessels, Akita, Japan, to develop a clinical PET scanner for quantitative assessment of cerebral and cardiovascular blood flow and metabolism. He lead an activity to develop three kinds of PET scanners which are for clinical use, including the Dual PET tomograph which scans both brain and heart simultaneously. He has also contributed to develop novel methodologies to quantitate regional myocardial perfusion, oxydative metabolism, which have been considered the gold standard in assesing in clinical populations. He then moved to National Cerebral and Cardiovascular Center - Research Institute, as a Director of Department of Investigated Radiology, in 1999. He and his colleagues developed a novel animal disease models of stroke, and cardiovascular diseases, together with the non-invasive methodologies to investigate their pathophysiology in PET, SPECT and MRI. He also contributed to make software and radio-labeled ligan producing devives to be approved as medical devices. They have been utilized in >400 clinical hospitals. He has an appointment to Turku PET Centre, and University of Turku in January, 2018, and continues to develop/improve the clinical methodology for assessing biological/physiological functional parametric images in vivo.  

Teaching

Interest areas in teaching are as follows:

1. PET, SPECT and MR instrumentation

2. Mathematical modeling of biological processes to interprete the sequential PET, SPECT and MR images as an application of the inverse problem

3. To learn pathophysiology from PET, SPECT and MR images.  

Research

Dr. Hidehiro Iida’s primary interest is the non-invasive imaging of bio-physiological functions and molecular processes using PET, SPECT and MRI modalities. He has been working on instrumentation and kinetic modeling-based methodologies. and contributed to develop several methods to quantitatively assess tissue perfusion, oxidative metabolism and other functions, in brain, heart and other organs. Some of those techniques have been utilized in a number of clinical researches as a gold standard, and also in clinical practice in patients with cerebral and cardiovascular diseases.

Publications

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Abnormal perinidal cerebral metabolism is associated with symptoms in brain arteriovenous malformation: New insights by a novel approach using oxygen-15 labelled tracers and PET (2025)

Journal of Cerebral Blood Flow and Metabolism
Hashio, Atsushi; Ikedo, Taichi; Mori, Hisae; Iida, Hidehiro; Maruyama, Daisuke; Yamagishi, Masayuki; Kitazawa, Yoshiaki; Hattori, Etsuko Yamamoto; Shimonaga, Koji; Hamano, Eika; Yamada, Kiyofumi; Imamura, Hirotoshi; Iihara, Koji; Kataoka, Hiroharu
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Performance Evaluation of New PET/CT DigitMI 930 (2025)

IEEE Transactions on Radiation and Plasma Medical Sciences
Zhang, Bo; Li, Bingxuan; Fang, Lei; Zhou, Xiaoyun; Li, Ang; Zhang, Xuan; Liu, Yang; Wang, Zhuo; Kao, Chien-Min; Liu, Yuqing; Zhu, Xiaohua; Wan, Lin; Xiao, Peng; Chen, Xun; Iida, Hidehiro; Knuuti, Juhani; Xie, Qingguo
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )

Spatial and temporal tracking of multi-layered cells sheet using reporter gene imaging with human sodium iodide symporter: a preclinical study using a rat model of myocardial infarction (2024)

European Journal of Nuclear Medicine and Molecular Imaging
Otani, Kentaro; Zeniya, Tsutomu; Kawashima, Hidekazu; Moriguchi, Tetsuaki; Nakano, Atsushi; Han, Chunlei; Murata, Shunsuke; Nishimura, Kunihiro; Koshino, Kazuhiro; Yamahara, Kenichi; Inubushi, Masayuki; Iida, Hidehiro
(A1 Vertaisarvioitu alkuperäisartikkeli tieteellisessä lehdessä )