Janne
Leivo
Senior Research Fellow, Biotechnology
Docent, Department of Life Technologies
InFLAMES Flagship
Ph.D., adj. prof.
MSCA-ITN proEVLifecycle (https://proevlifecycle.eu/)
Areas of expertise
Antibody engineering
Immunoassays
Extracellular vesicles
Exosomes
Prostate cancer
Research
The primary focus of our group is to design and validate novel biomarker concepts for early cancer detection and precision disease management. We have established a biomarker development pipeline based on glycovariants of various tumor markers and extracellular vesicles.
Our research is in the interface of basic and translational research, combining biomarker discovery, antibody and assay development and clinical validation to address the clinical need for the detection of most common solid cancers.
Publications
Immuno-based detection of extracellular vesicles in urine as diagnostic marker for prostate cancer (2015)
International Journal of Cancer
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Multiresidue Detection of Fluoroquinolones: Specificity Engineering of a Recombinant Antibody with Oligonucleotide-Directed Mutagenesis (2013)
Journal of Agricultural and Food Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Synthetic single-framework antibody library integrated with rapid affinity maturation by V-L shuffling (2011)
Protein Engineering, Design and Selection
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Directed antibody-engineering techniques and their applications in food immunoassays (2011)
Trends in Analytical Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Engineering of a broad-specificity antibody: Detection of eight fluoroquinolone antibiotics simultaneously (2011)
Analytical Biochemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))