Jatta
Helin
Senior Researcher, Turku PET Centre
PhD, Senior Researcher, Manager of In vivo Imaging
Quantitative modeling enabling kinetic analyses of animal PET imaging data
Contact
Areas of expertise
neurology
neuroscience
preclinical research
neuroimaging
positron emission tomography
nuclear medicine
medicine
pharmacy
pharmacology
drug discovery;
Research
The main goal of our research is to provide quantitative modeling tools that enable kinetic analyses of animal PET imaging data. Tracer kinetic models can be exploited to measure blood flow, membrane transport, metabolism, and ligand-receptor interactions noninvasively and quantitatively in various animal disease models tailored for metabolic disorders, and neurodegenerative and neuropsychiatric diseases. Ongoing projects aim at translating preclinically achieved data into human PET imaging protocols to be used in research and clinical settings.
Publications
In-target production of [11C]CH4 from a nitrogen/hydrogen gas target as a function of beam current, irradiation time, and target temperature (2024)
EJNMMI Radiopharmacy and Chemistry
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Glial reactivity in a mouse model of beta-amyloid deposition assessed by PET imaging of P2X7 receptor and TSPO using [11C]SMW139 and [18F]F-DPA (2024)
EJNMMI Research
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Mechanisms Leading to Increased Insulin-Stimulated Cerebral Glucose Uptake in Obesity and Insulin Resistance: A High-Fat Diet and Exercise Training Intervention PET Study with Rats (CROSRAT) (2024)
Journal of Functional Morphology and Kinesiology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Segmentation of Dynamic Total-Body [18F]-FDG PET Images Using Unsupervised Clustering (2023)
International Journal of Biomedical Imaging
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Direct Comparison of [18F]F-DPA with [18F]DPA-714 and [11C]PBR28 for Neuroinflammation Imaging in the same Alzheimer’s Disease Model Mice and Healthy Controls (2021)
Molecular Imaging and Biology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
(S)-[18F]THK5117 brain uptake is associated with Aβ plaques and MAO-B enzyme in a mouse model of Alzheimer's disease (2021)
Neuropharmacology
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Ruthenium-Mediated 18F-Fluorination and Preclinical Evaluation of a New CB1 Receptor Imaging Agent [18F]FPATPP (2020)
ACS Chemical Neuroscience
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Comparison of high and low molar activity TSPO tracer [18F]F-DPA in a mouse model of Alzheimer’s disease (2020)
Journal of Cerebral Blood Flow and Metabolism
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
Effect of genotype and age on cerebral [F-18]FDG uptake varies between transgenic APP(swe)-PS1(dE9) and Tg2576 mouse models of Alzheimer's disease (2019)
Scientific Reports
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
In vivo characterization of a novel norepinephrine transporter PET tracer [18F]NS12137 in adult and immature Sprague-Dawley rats (2019)
Theranostics
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))