Johanna Schleutker profile picture
Johanna
Schleutker
Professor, Institute of Biomedicine
PhD, Professor of Medical Genetics

Contact

+358 29 450 2726
+358 50 443 7237
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Cancer genetics
hereditary cancer
genomics
human genetics

Biography

Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.

Teaching

Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.

Research

The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.

Publications

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A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer (2014)

Nature Genetics
Al Olama AA, Kote-Jarai Z, Berndt SI, Conti DV, Schumacher F, Han Y, Benlloch S, Hazelett DJ, Wang Z, Saunders E, Leongamornlert D, Lindstrom S, Jugurnauth-Little S, Dadaev T, Tymrakiewicz M, Stram DO, Rand K, Wan P, Stram A, Sheng X, Pooler LC, Park K, Xia L, Tyrer J, Kolonel LN, Le Marchand L, Hoover RN, Machiela MJ, Yeager M, Burdette L, Chung CC, Hutchinson A, Yu K, Goh C, Ahmed M, Govindasami K, Guy M, Tammela TL, Auvinen A, Wahlfors T, Schleutker J, Visakorpi T, Leinonen KA, Xu J, Aly M, Donovan J, Travis RC, Key TJ, Siddiq A, Canzian F, Khaw KT, Takahashi A, Kubo M, Pharoah P, Pashayan N, Weischer M, Nordestgaard BG, Nielsen SF, Klarskov P, Røder MA, Iversen P, Thibodeau SN, McDonnell SK, Schaid DJ, Stanford JL, Kolb S, Holt S, Knudsen B, Coll AH, Gapstur SM, Diver WR, Stevens VL, Maier C, Luedeke M, Herkommer K, Rinckleb AE, Strom SS, Pettaway C, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, Cannon-Albright L, Cybulski C, Wokołorczyk D, Kluźniak W, Park J, Sellers T, Lin HY, Isaacs WB, Partin AW, Brenner H, Dieffenbach AK, Stegmaier C, Chen C, Giovannucci EL, Ma J, Stampfer M, Penney KL, Mucci L, John EM, Ingles SA, Kittles RA, Murphy AB, Pandha H, Michael A, Kierzek AM, Blot W, Signorello LB, Zheng W, Albanes D, Virtamo J, Weinstein S, Nemesure B, Carpten J, Leske C, Wu SY, Hennis A, Kibel AS, Rybicki BA, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Zheng SL, Batra J, Clements J, Spurdle A, Teixeira MR, Paulo P, Maia S, Slavov C, Kaneva R, Mitev V, Witte JS, Casey G, Gillanders EM, Seminara D, Riboli E, Hamdy FC, Coetzee GA, Li Q, Freedman ML, Hunter DJ, Muir K, Gronberg H, Neal DE, Southey M, Giles GG, Severi G; Breast and Prostate Cancer Cohort Consortium (BPC3); PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; COGS (Collaborative Oncological Gene-environment Study) Consortium; GAME-ON/ELLIPSE Consortium, Cook MB, Nakagawa H, Wiklund F, Kraft P, Chanock SJ, Henderson BE, Easton DF, Eeles RA, Haiman CA
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

HOXB13 G84E Mutation in Finland: Population-Based Analysis of Prostate, Breast, and Colorectal Cancer Risk (2013)

Cancer Epidemiology, Biomarkers and Prevention
Virpi H Laitinen, Tiina Wahlfors, Leena Saaristo, Tommi Rantapero, Liisa M Pelttari, Outi Kilpivaara, Satu-Leena Laasanen, Anne Kallioniemi, Heli Nevanlinna, Lauri Aaltonen, Robert L Vessella, Anssi Auvinen, Tapio Visakorpi, Teuvo L J Tammela, Johanna Schleutker
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array (2013)

Nature Genetics
Rosalind A Eeles, Ali Amin Al Olama, Sara Benlloch, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Maya Ghoussaini, Craig Luccarini, Joe Dennis, Sarah Jugurnauth-Little, Tokhir Dadaev, David E Neal, Freddie C Hamdy, Jenny L Donovan, Kenuir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen J Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue A Ingles, Esther M John, Richard B Hayes, Paul D P Pharoah, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-lbright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Amanda B Spurdle, Judith A Clements, anuel R Teixeira, Ed Dicks, Andrew Lee, Alison M Dunning, Caroline Baynes, Don Conroy, Melanie J Maranian, Shahana Ahmed, Koveela Govindasam, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, David P Dearnaley, Alan Horwich, Robert A Huddart, Vincent S Khoo, Christopher C Parker, Nicholas J Van As, Christopher J Woodhouse, Alan Thompson, Tim Dudderidge, Chris Ogden, Colin S Cooper, Artitaya Lophatananon, Angela Cox, Melissa C Southey, John L Hopper, Dallas R English, Markus Aly, Jan Adolfsson, Jiangfeng Xu, Siqun L Zheng, Meredith Yeager, Rudolf Kaaks, W Ryan Diver, Mia M Gaudet, Mariana C Stern, Roman Corral, Amit D Joshi, Ahva Shahabi, Tiina Wahlfors, Teuvo L J Tammela, Anssi Auvinen, Jarmo Virtamo, Peter Klarskov, Børge G Nordestgaard, M Andreas Røder, Sune F Nielsen, Stig E Bojesen, Afshan Siddiq, Liesel M FitzGerald, Suzanne Kolb, Erika M Kwon, Danielle M Karyadi, William J Blot, Wei Zheng, Qiuyin Cai, Shannon K McDonnell, Antje E Rinckleb, Bettina Drake, Graham Colditz, Dominika Wokolorczyk, Robert A Stephenson, Craig Teerlink, Heiko Muller, Dietrich Rothenbacher, Thomas A Sellers, Hui-Yi Lin, Chavdar Slavov, Vanio Mitev, Felicity Lose, Srilakshmi Srinivasan, Sofia Maia, Paula Paulo, Ethan Lange, Kathleen A Cooney, Antonis C Antoniou, Daniel Vincent, François Bacot, Daniel C Tessier, The COGSCOGSCOGSCOGS-Cancer Research UK GWGWAS-ELLELLELLIPSESE (part of GAMEME-ONON) Initiative72, The Australian Prostate Cancer Bioresource72, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology72, The UK ProtecT (Prostate testing for cancer and Treatment) Study Collaborators72, The PRACTCTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium72, Zsofia Kote-Jarai, Douglas F Easton
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Fine-mapping identifies multiple prostate cancer risk loci at 5p15, one of which associates with TERT expression (2013)

Human Molecular Genetics
Zsofia Kote-Jarai, Edward J Saunders, Daniel A Leongamornlert, Malgorzata Tymrakiewicz, Tokhir Dadaev, Sarah Jugurnauth-Little, Helen Ross-Adams, Ali Amin Al Olama, Sara Benlloch, Silvia Halim, Roslin Russel, Alison M Dunning, Craig Luccarini, Joe Dennis, David E Neal, Freddie C Hamdy, Jenny L Donovan, Ken Muir, Graham G Giles, Gianluca Severi, Fredrik Wiklund, Henrik Gronberg, Christopher A Haiman, Fredrick Schumacher, Brian E Henderson, Loic Le Marchand, Sara Lindstrom, Peter Kraft, David J Hunter, Susan Gapstur, Stephen Chanock, Sonja I Berndt, Demetrius Albanes, Gerald Andriole, Johanna Schleutker, Maren Weischer, Federico Canzian, Elio Riboli, Tim J Key, Ruth C Travis, Daniele Campa, Sue Ingles, Esther M John, Richard B Hayes, Paul Pharoah, Kay-Tee Khaw, Janet L Stanford, Elaine A Ostrander, Lisa B Signorello, Stephen N Thibodeau, Dan Schaid, Christiane Maier, Walther Vogel, Adam S Kibel, Cezary Cybulski, Jan Lubinski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Amanda Spurdle, Judith A Clements, Manuel R Teixeira, Koveela Govindasami, Michelle Guy, Rosemary A Wilkinson, Emma J Sawyer, Angela Morgan, Ed Dicks, Caroline Baynes, Don Conroy, Stig E Bojesen, Rudolf Kaaks, Daniel Vincent, Franc¸ois Bacot, Daniel C Tessier, COGS-CRUK GWASELLIPSE (Part of GAME-ON) Initiative}, The UK Genetic Prostate Cancer Study Collaborators/British Association of Urological Surgeons’ Section of Oncology, The UK ProtecT Study Collaborators, The PRACTICAL Consortium, Douglas F Easton and Rosalind A Eeles
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))