Johanna Schleutker profile picture
Johanna
Schleutker
Professor, Institute of Biomedicine
PhD, Professor of Medical Genetics

Contact

+358 29 450 2726
+358 50 443 7237
Kiinamyllynkatu 10
20520
Turku

Areas of expertise

Cancer genetics
hereditary cancer
genomics
human genetics

Biography

Johanna Schleutker got her PhD in 1995 in University of Turku, Faculty of Medicine.The topic of her doctoral thesis was "Linkage disequilibrium is Salla disease; positioning of the sialic acid transport defect". She then moved to University of Tampere, and did her post doc in 1996-1998 in the Cancer Genetics research group of Professor Olli Kallioniemi. Her career continued in the US where she spent the years of 1999-2000 working as a research associate at the National Human Genome Research Institute, National Institutes of Health, Bethesda, MD. During the NIH years, she studied genetics of familial prostate cancer in the group of Dr. Jeffrey M.Trent. After her return to Finland, Schleutker started her own research group in 2001 at the Insitute of Medical Technology, University of Tampere, and has ever since focused her studies on genetics and genetic susceptibility of prostate and breast cancer. Schleutker got a professorship in University of Tampere in 2008. In 2011 she started as a professor of medical genetics in University of Turku.

Teaching

Genetics, cancer genetics, hereditary cancer, genomics, molecular biology.

Research

The Schleutker group "Genetic Predisposition to Cancer" is studying both breast and prostate cancer genetics, the main emphasis being on prostate cancer. Of all cancers, prostate cancer (PrCa) has been reported as one of the most heritable diseases: genetic factors have been estimated to account for 57% of the risk. The goal is to identify and characterize predisposing genes and variants, especially those affecting aggressive outcome, including treatment responses to therapies. Further, the aim is to develop tools for prognostic purposes, i.e. prognostic biomarkers. The group has identified many significant genomic risk regions, candidate genes and variants, which have been then further profiled and characterized by functional studies. The group has produced (by 2021) 12 PhD degrees and published over 190 original, peer-reviewed articles in international journals.

Publications

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Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis (2017)

International Journal of Cancer
Taylor AE, Martin RM, Geybels MS, Stanford JL, Shui I, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pashayan N, Khaw KT, Blot W, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Donovan J, Munafo MR
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study (2017)

BMJ
Dimitrakopoulou VI, Tsilidis KK, Haycock PC, Dimou NL, Al-Dabhani K, Martin RM, Lewis SJ, Gunter MJ, Mondul A, Shui IM, Theodoratou E, Nimptsch K, Lindstrom S, Albanes D, Kuhn T, Key TJ, Travis RC, Vimaleswaran KS, Kraft P, Pierce BL, Schildkraut JM, Schildkraut JM; GECCO Consortium; PRACTICAL Consortium; GAME-ON Network
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study (2017)

International Journal of Cancer
Brunner C, Davies NM, Martin RM, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles G, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Donovan J, Hamdy FC, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Pandha H, Zuccolo L
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Geneettinen alttius syövälle (2017)

Duodecim
Kankuri-Tammilehto Minna, Schleutker Johanna
(Vertaisarvioitu katsausartikkeli tieteellisessä aikakauslehdessä (A2))

Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer (2017)

BMC Genomics
Hilker C., Windebank S., Meyer J., Zuber V., Mills I., Andreassen O., Witoelar A., Bettella F., Kote-Jarai Z., Easton D., Eeles R., Urbanucci A., Giles G., Muir K., Benlloch S., Al Olama A., Weischer M., Travis R., Neal D., Pharoah P., Wiklund F., Gronberg H., Haiman C., Schleutker J., Maier C., Kibel A., Cybulski C., Cannon-Albright L., Khaw K., Stanford J., Blot W., Thibodeau S., Pandha H., Teixeira M., Humphreys M., Chenevix-Trench G., Park J., Brenner H., Batra J., Kaneva R., Houlston R., Rosenberger A., Landi M., Caporaso N., Han Y., Hung R., Bickeböller H., Brennan P., Easton D., Michailidou K., Christiani D., Amos C., Wu X., Ye Y., Heinrich J., Risch A., Offit K., Dennis J., McGuffog L., Couch F., Berchuck A., Antoniou A., Bolla M., Wang Q., Tessier D., Simard J., Gonzalez-Neira A., Benitez J., Luccarini C., Dicks E., Lee A., Dunning A., Cunningham J., Nordestgaard B., Nielsen S., Bojesen S., Robidoux F., LaBoissière S., Vincent D., Bacot F.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Blood lipids and prostate cancer: a Mendelian randomization analysis (2016)

Cancer Medicine
Bull CJ, Bonilla C, Holly JMP, Perks CM, Davies N, Haycock P, Yu OHY, Richards JB, Eeles R, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, MacInnis RJ, Wiklund F, Gronberg H, Haiman CA, Schleutker J, Nordestgaard BG, Travis RC, Neal D, Pashayan N, Khaw KT, Stanford JL, Blot WJ, Thibodeau S, Maier C, Kibel AS, Cybulski C, Cannon-Albright L, Brenner H, Park J, Kaneva R, Batra J, Teixeira MR, Micheal A, Pandha H, Smith GD, Lewis SJ, Martin RM
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation (2016)

Nature Communications
Gusev A, Shi H, Kichaev G, Pomerantz M, Li F, Long HW, Ingles SA, Kittles RA, Strom SS, Rybicki BA, Nemesure B, Isaacs WB, Zheng W, Pettaway CA, Yeboah ED, Tettey Y, Biritwum RB, Adjei AA, Tay E, Truelove A, Niwa S, Chokkalingam AP, John EM, Murphy AB, Signorello LB, Carpten J, Leske MC, Wu SY, Hennis AJM, Neslund-Dudas C, Hsing AW, Chu L, Goodman PJ, Klein EA, Witte JS, Casey G, Kaggwa S, Cook MB, Stram DO, Blot WJ, Eeles RA, Easton D, Kote-Jarai Z, Al Olama AA, Benlloch S, Muir K, Giles GG, Southey MC, Fitzgerald LM, Gronberg H, Wiklund F, Aly M, Henderson BE, Schleutker J, Wahlfors T, Tammela TLJ, Nordestgaard BG, Key TJ, Travis RC, Neal DE, Donovan JL, Hamdy FC, Pharoah P, Pashayan N, Khaw KT, Stanford JL, Thibodeau SN, McDonnell SK, Schaid DJ, Maier C, Vogel W, Luedeke M, Herkommer K, Kibel AS, Cybulski C, Wokolorczyk D, Kluzniak W, Cannon-Albright L, Teerlink C, Brenner H, Dieffenbach AK, Arndt V, Park JY, Sellers TA, Lin HY, Slavov C, Kaneva R, Mitev V, Batra J, Spurdle A, Clements JA, Teixeira MR, Pandha H, Michael A, Paulo P, Maia S, Kierzek A, Conti DV, Albanes D, Berg C, Berndt SI, Campa D, Crawford ED, Diver WR, Gapstur SM, Gaziano JM, Giovannucci E, Hoover R, Hunter DJ, Johansson M, Kraft P, Le Marchand L, Lindstrom S, Navarro C, Overvad K, Riboli E, Siddiq A, Stevens VL, Trichopoulos D, Vineis P, Yeager M, Trynka G, Raychaudhuri S, Schumacher FR, Price AL, Freedman ML, Haiman CA, Pasaniuc B, Cook M, Guy M, Govindasami K, Leongamornlert D, Sawyer EJ, Wilkinson R, Saunders EJ, Tymrakiewicz M, Dadaev T, Morgan A, Fisher C, Hazel S, Livni N, Lophatananon A, Pedersen J, Hopper JL, Adolfson J, Stattin P, Johansson JE, Cavalli-Bjoerkman C, Karlsson A, Broms M, Auvinen A, Kujala P, Maeaettaenen L, Murtola T, Taari K, Weischer M, Nielsen SF, Klarskov P, Roder A, Iversen P, Wallinder H, Gustafsson S, Cox A, Brown P, George A, Marsden G, Lane A, Davis M, Zheng W, Signorello LB, Blot WJ, Tillmans L, Riska S, Wang L, Rinckleb A, Lubiski J, Stegmaier C, Pow-Sang J, Park H, Radlein S, Rincon M, Haley J, Zachariah B, Kachakova D, Popov E, Mitkova A, Vlahova A, Dikov T, Christova S, Heathcote P, Wood G, Malone G, Saunders P, Eckert A, Yeadon T, Kerr K, Collins A, Turner M, Srinivasan S, Kedda MA, Alexander K, Omara T, Wu HH, Henrique R, Pinto P, Santos J, Barros-Silva J
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array (2016)

British Journal of Cancer
Edward J Saunders, Tokhir Dadaev, Daniel A Leongamornlert, Ali Amin Al Olama, Sara Benlloch, Graham G Giles, Fredrik Wiklund, Henrik Grönberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, David Neal, Nora Pasayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen N Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Y Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Koveela Govindasami, Ken Muir, The UK Genetic Prostate Cancer Study Collaborators, The UK ProtecT Study Collaborators, The PRACTICAL Consortium, Douglas F Easton, Rosalind A Eeles, Zsofia Kote-Jarai
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))