Jorma Toppari profile picture
Jorma
Toppari
InFLAMES Flagship
Professor, Institute of Biomedicine
MD, PhD

Contact

+358 29 450 2826
+358 40 180 2600
Kiinamyllynkatu 10
20520
Turku

Links

Publications J Toppari 2018 Nov.pdf
CV_Jorma_Toppari_ 2018_Nov.pdf
ORCID

Areas of expertise

Pediatric endocrinology
reproductive health
endocrine disruption
testis
type 1 diabetes

Biography

Professor Jorma Toppari (H-index 68) is an international expert in environmental endocrine disruption, male reproduction and type 1 diabetes. He is a principal investigator in a NIH-funded cohort study The Environmental Determinants of Diabetes in the Young (TEDDY) and in the Finnish Type 1 Diabetes Prediction and Prevention Study (DIPP). He is leading a joint Finnish-Danish birth cohort study exploring the genetic and environmental aspects of human reproduction. 

Teaching

Basic and clinical endocrinology, particularly pediatric and reproductive endocrinology, endocrine disruption, reproductive toxicology

Research

The aim of our research is to identify risk factors of reproductive health and type 1 diabetes (T1D) to make risk management possible and prevent health problems. We are performing a comprehensive reproductive health study for 19-year-old men that we have followed up prospectively from pregnancy. We focus now our studies on sperm epigenome. We are studying the role of retinoblastoma protein (Rb) and E2F3 transcription factors in gonadal development and whether endocrine disruptors affect reproductive health. In the Finnish type 1 Diabetes Prediction and Prevention (DIPP) study and in The Environmental Determinants of Diabetes in the Young (TEDDY) study we are exploring the early determinants of T1D in large child cohorts with increased genetic risk.

Publications

Sort by:

Distinct transcriptomic profiles in children prior to the appearance of type 1 diabetes-linked islet autoantibodies and following enterovirus infection (2023)

Nature Communications
Lin Jake, Moradi Elaheh, Salenius Karoliina, Lehtipuro Suvi, Häkkinen Tomi, Laiho Jutta E., Oikarinen Sami, Randelin Sofia, Parikh Hemang M., Krischer Jeffrey P., Toppari Jorma, Lernmark Åke, Petrosino Joseph F., Ajami Nadim J., She Jin-Xiong, Hagopian William A., Rewers Marian J., Lloyd Richard E., Rautajoki Kirsi J., Hyöty Heikki, Nykter Matti; the TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Gluten-free diet adherence in children with screening-detected celiac disease using a prospective birth cohort study (2023)

PLoS ONE
Mehta Pooja, Li Qian, Stahl Marisa, Uusitalo Ulla, Lindfors Katri, Butterworth Martha D, Kurppa Kalle, Virtanen Suvi, Koletzko Sibylle, Aronsson Carin, Hagopian William A, Rewers Marian J, Toppari Jorma, Ziegler Anette-G, Akolkar Beena, Krischer Jeffrey P, Agardh Daniel, Liu Edwin, TEDDY Study Group
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Exposure to Phthalates in European Children, Adolescents and Adults since 2005: A Harmonized Approach Based on Existing HBM Data in the HBM4EU Initiative (2023)

Toxics
Vogel N., Lange R., Schmidt P., Rodriguez Martin L., Remy S., Springer A., Puklová V., Černá M., Rudnai P., Középesy S., Janasik B., Ligocka D., Fábelová L., Kolena B., Petrovicova I., Jajcaj M., Eštóková M., Esteban-Lopez M., Castaño A., Tratnik J.S., Stajnko A., Knudsen L.E., Toppari J., Main K.M., Juul A., Andersson A.M., Jørgensen N., Frederiksen H., Thomsen C., Sakhi A.K., Åkesson A., Hartmann C., Dewolf M.C., Koppen G., Biot P., Den Hond E., Voorspoels S., Gilles L., Govarts E., Murawski A., Gerofke A., Weber T., Rüther M., Gutleb A.C., Guignard C., Berman T., Koch H.M., Kolossa-Gehring M.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))

Plasma protein biomarkers predict the development of persistent autoantibodies and type 1 diabetes 6 months prior to the onset of autoimmunity (2023)

Cell Reports Medicine
Nakayasu E.S., Bramer L.M., Ansong C., Schepmoes A.A., Fillmore T.L., Gritsenko M.A., Clauss T.R., Gao Y., Piehowski P.D., Stanfill B.A., Engel D.W., Orton D.J., Moore R.J., Qian W.J., Sechi S., Frohnert B.I., Toppari J., Ziegler A.G., Lernmark Å., Hagopian W., Akolkar B., Smith R.D., Rewers M.J., Webb-Robertson B.J.M., Metz T.O.
(Vertaisarvioitu alkuperäisartikkeli tai data-artikkeli tieteellisessä aikakauslehdessä (A1))
People search